《含氮有机化合物 (4)讲稿.ppt》由会员分享，可在线阅读，更多相关《含氮有机化合物 (4)讲稿.ppt（70页珍藏版）》请在taowenge.com淘文阁网|工程机械CAD图纸|机械工程制图|CAD装配图下载|SolidWorks_CaTia_CAD_UG_PROE_设计图分享下载上搜索。
1、关于含氮有机化合物(4)第一页，讲稿共七十页哦CH3CH2NO2NO2CH3RNO2RONO第二页，讲稿共七十页哦CH3ONO+-12-12NO0.137 nmNO0.122 nmRNOORNOO+第三页，讲稿共七十页哦RONOCH3(CH2)4Br+AgNO2CH3(CH2)4NO2+CH3(CH2)4ONO7580%14%第四页，讲稿共七十页哦RNO2HRNH2HNO2HNOHNHOHNH2第五页，讲稿共七十页哦RCHNOORCHNOHORCHNOHONaOH第六页，讲稿共七十页哦3HCHO +CH3NO2 OHHOCH2CCH2OHNO2CH2OH第七页，讲稿共七十页哦RCH2NO2HO
2、NORCNOHNO2+H2OR2CHNO2HONOR2CNO2NO+H2OR3CNO2HONO第八页，讲稿共七十页哦NClOONHOOO第九页，讲稿共七十页哦 RNH2R2NHR3N R4N+X-季铵盐R4N+OH-季铵碱NH3NH4+X-铵盐NH4OH第十页，讲稿共七十页哦 CH2NHCH3CH2NH2 CH3CH2CHCH2CH2CH2CH3 CH3CH2CHCHNHCH3NHCH2CH3CH3H3C第十一页，讲稿共七十页哦 (CH3)2CH4N+I-N+CH3 OH-CH2CH2OHCH3CH3 第十二页，讲稿共七十页哦NHH3CHsp3112.9o105.9o第十三页，讲稿共七十页哦C
3、H3N+H5C2CH2CH=CH2phCH3N+C2H5CH2=CHCH2phNR1NR1R2R3R3R2第十四页，讲稿共七十页哦 RNH2 +H2O RNH3+OH-RNH2 +HXRNH3+X-OH-RNH2第十五页，讲稿共七十页哦CH3NH2 (CH3)2NH (CH3)3N NH3 NH2 3.38 3.27 4.21 4.76 9.37 NNH2CH3NH2O2N13.0 8.92第十六页，讲稿共七十页哦CH3N+CH3CH3HOH2CH3N+HHHOH2OH2OH2CH3N+CH3HHOH2OH2第十七页，讲稿共七十页哦RXR4N+X-NH3RXSN2RNH2RXR2NHRXR3N
4、第十八页，讲稿共七十页哦RCNR2 +HClORCNHR +HClORCNH2 +HClORCCl +RNH2ONH3R2NH氢氧化钠氢氧化钠或吡啶或吡啶RCCl +R3NORCCl +RNH2O第十九页，讲稿共七十页哦RNH2R2NHR3NSO2ClSO2NHRSO2NR2不反应（不溶于NaOH水溶液）NaOHSO2NRNa+-RNH2R2NHR3NSO2ClSO2NHRSO2NR2不反应（不溶于NaOH水溶液）NaOHSO2NRNa+-RNH2R2NHR3NSO2ClSO2NHRSO2NR2不反应（不溶于NaOH水溶液）NaOHSO2NRNa+-RNH2R2NHR3NSO2ClSO2NHR
5、SO2NR2不反应（不溶于NaOH水溶液）NaOHSO2NRNa+-RNH2R2NHR3NSO2ClSO2NHRSO2NR2不反应（不溶于NaOH水溶液）NaOHSO2NRNa+-RNH2R2NHR3NSO2ClSO2NHRSO2NR2不反应（不溶于NaOH水溶液）NaOHSO2NRNa+-第二十页，讲稿共七十页哦CH3CH2CH2+Cl-+N2醇、烯、卤代烃等 CH3CH2CH2NH2NaNO2HCl1o胺CH3CH2CH2N+NCl-重氮盐NH2 +NaNO2 +HClO5oCN2+Cl-第二十一页，讲稿共七十页哦Ar(R)NH(或R2NH)+HONO2o胺致癌剂致癌剂3o胺N(CH3)2
6、+HONOR3N+HNO2R3NH+NO2-Ar(R)NNO(或R2NNO)N-亚硝基胺ONN(CH3)2(绿色结晶)第二十二页，讲稿共七十页哦NH2+3Br2H2ONH2BrBrBr+3HBrNH2(CH3CO)2ONHCOCH3Br2无水CH3COOHNHCOCH3BrNH2BrH+or OH-第二十三页，讲稿共七十页哦NH2浓浓H2SO4N+H3OSO3H1802000CH2ONHSO3H重重排排NH2SO3H第二十四页，讲稿共七十页哦CH2N+(CH3)3Cl-C12H25N+(CH3)3Cl-R3N +RIR3N+R I-CH2Cl +(CH3)3N第二十五页，讲稿共七十页哦R4N+
7、X-+Ag2OH2O(CH3)3N+CH3OHR4N+OH-+AgXN+CH3CH3CH3CH3OH-1301350C第二十六页，讲稿共七十页哦CH3CH2CHCHCH2H+N(CH3)3HOH-+2N(CH3)3+H2O55.7%1.3%2CH3CH2CH2CH=CH2+CH3CH2CH=CHCH3第二十七页，讲稿共七十页哦CH3CH2CHCH CH2HN(CH3)3 HOHCH3CH2CH2CH=CH2 +N(CH3)3 +H2O+-CH3CH2CHCHCH2H+N(CH3)3HOH-第二十八页，讲稿共七十页哦3)CH3CH2CH2N(CH3)2+CH2CH2+H2O3)CH3CHCH2+
8、(CH3)3N+H2OCH3CH2CH2N+CH2CH3OH-CH3CH3CH3CH2CH2N+(CH3)3OH-CH3CH2CH2NHCH2CH31)2CH3I2)Ag2O,H2OCH3CH2CH2N(CH3)21)CH3I2)Ag2O,H2O第二十九页，讲稿共七十页哦?试试2次彻底甲基化2次Hofmann消除NHCH3第三十页，讲稿共七十页哦 NH3RXSN2RNH2RXRXRXR2NHR3NR4N+X-CH3ClKNH2/NH3(l)CH3NH2CH3NH2+68%32%第三十一页，讲稿共七十页哦CH3ClCl-_CH3CH3NH2CH3NH2+NH2-68%32%第三十二页，讲稿共七十
9、页哦 NOHNa,C2H5OHor LiAlH4NH2 第三十三页，讲稿共七十页哦COH2/Ni+NH3CHNH2C OH2/Ni+RNH2CHNHRC OH2/Ni+R2NHCHNR2+NH3RCH2CHORCHCHNH2烯烯胺胺RCH2CHNH亚胺H2/NiRCH2CH2NH2第三十四页，讲稿共七十页哦KOHN-OOKOHH2ORNH2 +COO-COO-OOONH3NHOO1oRXSN2NROO第三十五页，讲稿共七十页哦 RCNH2OBr2,NaOH H2ORNH2第三十六页，讲稿共七十页哦 NH2 O5oCN2+Cl-+NaCl +H2ONaNO2+HCl第三十七页，讲稿共七十页哦NN
10、:+NN:ArOHNNArOH+-碱OOHNNAr碱芳基重氮酸芳基重氮酸第三十八页，讲稿共七十页哦N2+HSO4H+H2O+H2OOH2+N2+N2OH +N2-H+OH第三十九页，讲稿共七十页哦N+NX-CuXHClN+NX-CuCNKCN碘代物的制备碘代物的制备X+N2（X=Cl、Br）CN +N2IN+NCl-KI第四十页，讲稿共七十页哦CuBrHBrClBr讨论讨论HNO3H2SO4NO2NO2ClNaNO2HBrN2+Br-ClFeCl3Cl2HClFeNH2ClBrCl第四十一页，讲稿共七十页哦+N2N2+Cl-H3PO2H2O+N2N2+HSO4-CH3CH2OH第四十二页，讲稿
11、共七十页哦 NN+NN+N2+Cl-+OHNaOHH2ONNOH第四十三页，讲稿共七十页哦N2+Cl-+N(CH3)2CH3COOHH2O NNN(CH3)2第四十四页，讲稿共七十页哦NNO-Na+NR2H+OHH+OH2+NHR2+N2+Cl-NaOHNNOHNaOH第四十五页，讲稿共七十页哦N2+Cl-+NH2CH3COONaCH3COOH,200CNNNHPhNH3+Cl-PhNH230450CNNNH2第四十六页，讲稿共七十页哦C H2NNCH2NNCH2NNCH2NN第四十七页，讲稿共七十页哦 RCOOCH3 +N2RCOOH +CH2N2-N2R C O O C H3OCH3OHC
12、H2N2RCOOH +CH2N N RCOO +CH3N N第四十八页，讲稿共七十页哦ArndtEistert ReactionAg2OH2ORCH2COOHCORClCORCHN22CH2N2CORCH2Cl+N2CH2N2第四十九页，讲稿共七十页哦OCCHRWolff重排CORCHNNCl H-Cl-CORCHNNHCH2NNAg2OH2ORCH2COOHCORCl +CH2NN CORCHNN_CORCH第五十页，讲稿共七十页哦 (Molecular Rearrangements）Nucleophilic Rearrangement 第五十一页，讲稿共七十页哦CCZLCCZ L-H+CC
13、Z+12重重排排CCZ+Nu-H+CCZNuCCZ第五十二页，讲稿共七十页哦Pinacolic RearrangementCH3CCH3OHCCH3CH3OHH+H2OCH3CCH3OHCCH3CH3OH2+CH3CCH3OHCCH3CH3+CH3CCH3CCH3CH3OH+CH3CCH3OCCH3CH3CH3CCH3OHCCH3CH3+H+第五十三页，讲稿共七十页哦CCR2R1R3R4OHOHH+COHCH2OHPhPh+CCH2OHPhPhPh2CHCHO+CCHOHPhPhHH+-第五十四页，讲稿共七十页哦PhCOHCPhOHCH3CH3H+PhCCPhOHCH3CH3+Ph2CHCOC
14、H3CH3H+Ph2C COH+H3C CH3第五十五页，讲稿共七十页哦CH3OClCH2=CH R3CR2CH CH3H第五十六页，讲稿共七十页哦CCR2R1R3R4OH+CCR2R1R3R4OH+CCR2R1R3R4OHNH2HNO2N2CCR2R1R3R4OH+第五十七页，讲稿共七十页哦 Wagner-Meerwein rearrangementH+CH3CCH3CH3CH2OHH2OCH3CCH3CH3CH2OH2CH3CCH3CH3CH2H+Cl-CH3CCH3CH2CH3第五十八页，讲稿共七十页哦 Beckmann RearrangementCRRNOHH+CRRNHOCRRNOH
15、2H2O+_CRRN+CRRNH2OH2O+CRRNHO_H+第五十九页，讲稿共七十页哦CCH3PhNHO RCNH2OBr2,NaOH H2ORNH2PCl5CPhCH3NOH第六十页，讲稿共七十页哦CCZ+12重重排排CCZ+12CCZL L-Nu-CCZNuEt2OCCH3CNHOC2H5HCH2C2H5H2SO4CH3CONHCC2H5HCH2C2H5第六十一页，讲稿共七十页哦OHCH3OHCH3H2SO4OCH3CH3CH3OHOHCH3H2SO4CH3CH3O第六十二页，讲稿共七十页哦CH3OHOHCH3H2SO4CH3CH3O123456123456123456OHOHCH3CH
16、3第六十三页，讲稿共七十页哦 CH3C PhOCF3CO3HCH3C OPhO第六十四页，讲稿共七十页哦CF3COOHOCH3C PhOH+CH3C PhOHCF3COOHOCH3CPhOHCF3C O OOH+CH3COPhOH+CF3COOHH+CH3C OPhO第六十五页，讲稿共七十页哦CF3CO3HCH2Cl2CH3C C(CH3)3OPh C CH2CH3OCH2Cl2CF3CO3H第六十六页，讲稿共七十页哦 CCZL L+CCZ12重重排排CCZ-第六十七页，讲稿共七十页哦Ph CCH3CH3CH2CHO(t C4H9O)2Ph CCH3CH3CH2COPh CCH3CH3CH2H rearrangementCCH3CH3CH2PhH HCCH3CH3CH2PhCOPh CCH3CH3CH3第六十八页，讲稿共七十页哦 NHNHH+H2NNH2第六十九页，讲稿共七十页哦感谢大家观看感谢大家观看第七十页，讲稿共七十页哦