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1、NEURAL REGENERATION RESEARCH Volume 7,Issue 10,April 2012 Cite this article as:Neural Regen Res.2012;7(10):792-799.792 Yanli Xu,M.D.,Professor,Medical College of Hebei University of Engineering,Handan 056009,Hebei Province,China Corresponding author:Jianzhong Zhang,M.D.,Doctoral supervisor,State Key
2、 Laboratory for Infectious Disease Prevention and Control;National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China Received:2012-01-19 Accepted:2012-03-28(N20120406006/Z)Xu YL,Li MJ,Liu ZJ,Xi AP,Zhao CX,Zhang JZ.Scienti
3、fic literature addressing detection of monosialoganglioside:a 10-year bibliometric analysis.2012;7(10):792- www.nrronline.org doi:10.3969/j.issn.1673-5374.2012.10.012 Scientific literature addressing detection of monosialoganglioside A 10-year bibliometric analysis Yanli Xu1,Miaojing Li2,Zhijun Liu1
4、,Aiping Xi1,Chaoxian Zhao1,Jianzhong Zhang3 1Medical College of Hebei University of Engineering,Handan 056009,Hebei Province,China 2School of Public Health,Mudanjiang Medical University,Mudanjiang 157011,Heilongjiang Province,China 3State Key Laboratory for Infectious Disease Prevention and Control;
5、National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China Abstract OBJECTIVE:The study was undertaken to explore a bibliometric approach to quantitatively assess the research on detection of monosialoganglioside from 200
6、2 to 2011.DATA RETRIEVAL:A bibliometric analysis based on the publications on Web of Science was performed using key words such as“monosialoganglioside”,“colloidal gold”,“high performance liquid chromatography”and“detection”.SELECTION CRITERIA:(1)Research articles on the detection of monosialogangli
7、oside;(2)researches on human and animal fundamentals,clinical trials and case reports;(3)article types:article,review,proceedings paper,note,letter,editorial material,discussion,book chapter;(4)Publication year:2002-2011.Exclusion criteria:(1)unrelated articles;(2)type of articles:correction;(3)arti
8、cles from following databases:all databases related to social science and arts&humanities in Web of Science were excluded.MAIN OUTCOME MEASURES:(1)distribution of subject areas;(2)number of publications annually;(3)document type and language of publications;(4)distribution of institutions;(5)distrib
9、ution of output in journals;(6)the number of countries in which the article is published;(7)top cited paper.RESULTS:Overall population stands at 1 880 research articles addressing detection of monosialoganglioside in Web of Science during the study period.Articles(1 599)were the most frequently used
10、 document type comprising 85.05%,followed by meeting abstracts,reviews and proceedings papers.The distribution of subject categories showed that monosialoganglioside research covered both clinical and basic science research.The USA,Japan,and Italy were the three most productive countries,and the pub
11、lication numbers in the USA were highest with 559 papers.The University of Milan,Nagoya University,and Kinki University are the most productive institutions regarding detection of monosialoganglioside.In 559 articles published by Americans,Medical College of Georgia ranked the first with 30 articles
12、,followed by University of Medicine and Dentistry of New Jersey(28 articles),Cornell University(24 articles)and Johns Hopkins University(24 articles).In 442 articles published by Japanese,Nagoya University ranked the first with 40 articles,followed by Kinki University(36 articles),and Dokkyo Univers
13、ity(31 articles).Though the total number of publications by Japanese is smaller than Americans,the top three institutions published more publications than American institutions.There is a markedly increase in the number of publications on the subject detection of monosialoganglioside in 2004,which t
14、he peak in the past 10 years.The valley bottom of the subject appeared in 2005.In total,the research is increased with time prolonged.Journal of Neurochemistry,Journal of Biological Chemistry and Journal of Neuroimmunology were core subject journals in monosialoganglioside studies.CONCLUSION:This st
15、udy highlights the topics in detection of monosialoganglioside research that are being published around the world.Key Words:monosialoganglioside;colloidal gold;high performance liquid chromatography;bibliometrics;Web of Science;scientific literature Abbreviations:GM1,monosialoganglioside;SCI-E,Scien
16、ce Citation Index Expanded;TLC,thin-layer chromatography www.nrronline.org www.nrronline.org Xu YL,et al./Neural Regeneration Research.2012;7(10):792-799.793 INTRODUCTION Monosialogangliosides(GM1),sialic-acid-containing glycosphingolipids,are involved in numerous biological processes and closely re
17、lated to cell-cell recognition,adhesion and signal conduction,and play essential roles in severe pathologies,with predilection in those of the central nervous system.GM1 is mainly composed of ceramide and oligosaccharide chains,and it is the only ganglioside that can permeate the blood-brain barrier
18、.It was first reported by Klenk in 1935 from the brain of a patient diagnosed as having had infantile amaurotic idiocy(Tay-Sachs disease)combined with Niemann-Pick disease1.He identified this glycolipid as the storage material typically found in Tay-Sachs disease2.He also isolated this lipid from no
19、rmal human brain,and named it ganglioside because of its glycolipid character and its occurrence in ganglion cells3.In 1951,the presence of sialic acid at the surface of cell membranes was first demonstrated by Yamakawa et al 4.He isolated a sialic acid-containing substance from 100 g of freeze-drie
20、d ghosts obtained from 10 L of packed horse erythrocytes and named the glycolipid“hematoside”,which has the structure of ceramide(11)GLc(41)Gal(32)4-5.Sialic acid is the main ingredients for GM1,which participates in the process of cell growth and differentiation6.The pre-column derivatizing method7
21、 and Hypersil NH2 analyzing method8 have been used in GM1 analysis.However,both of methods are hard to use for complex procedure,large cost or short lifecycle.Ganglioside composition and quantity in different matrices as well as their distribution and expression at the cell surface have been demonst
22、rated by thin-layer chromatography(TLC)as well as immunochemical and immunohistochemical methods9.Because of their detection principles and reduced sensitivity,these methods that are based on comparisons,typically provide information on the major components present in the mixture and less or at all
23、on the minor species known to be of biomarker value.Colorimetric method can only determine the total contents of GM110-11,as to high performance liquid chromatography,with poor specificity,cannot control the free sialic acid and GM1 quality effectively in clinical application12.Recent studies have s
24、hown that colloidal gold can be used in GM1 detection13,but the detailed mechanism still needs to be investigated.The bibliometric approach is used for information science and to quantitatively analyze numbers of publications in the library,recently,it was introduced to scientific field to guide stu
25、dying certain subject study from the distribution patterns of the authorship,publication metrics,and citations of literatures,and to investigate research trends in certain field.This study is designed to compare different detection methods for GM1 from published research papers found on Web of Scien
26、ce from 2002 to 2011.DATA SOURCES AND METHODOLOGY Design Bibliometric study.Time and setting The study was performed at the Medical College of Hebei University of Engineering on February 18,2012.Data retrieval The search was primarily undertaken from the online version of the Science Citation Index
27、Expanded(SCI-E,1899-present),accessed via Web of Science,Philadelphia,PA,USA.According to Thomson Reuters,SCI-E indexed 8 436 major journals with citation references across 173 scientific disciplines in 2011.SCI-E is considered as one of the most comprehensive and relevant coverage of bibliometric i
28、nformation and journals,which enables researchers to find data,to analyze trends,cross referencing journals and researchers.The Web of Science containing following databases:SCI-E-1899-present;Conference Proceedings Citation Index-Science(CPCI-S)-1991-present;Book Citation Index-Science(BKCI-S)-2005
29、-present.Social Sciences Citation Index(SSCI)-1898-present;Arts&Humanities Citation Index(A&HCI)-1975-present;Conference Proceedings Citation Index-Social Science&Humanities(CPCI-SSH)-1991-present;Book Citation IndexSocial Sciences&Humanities(BKCI-SSH)-2005-present;Current Chemical Reactions(CCR-EXP
30、ANDED)-1985-present;Index Chemicus(IC)-1993-present.In this paper,Web of Science was searched to determine the number of articles published on GM1 detection.Inclusive criteria(1)Articles studied on the GM1 detection.(2)Type of articles includes articles,reviews,proceedings paper,notes,letter,editori
31、al material,discussion and book chapters.(3)Year of publication:2002-2011.(4)Citation databases:SCI-E-1899-present;Conference Proceedings Citation Index-Science(CPCI-S)-1991-present;Book Citation Index-Science(BKCI-S)-2005-present.Exclusive criteria(1)Articles related to other types of ganglioside r
32、ather than GM1.(2)Type of articles:correction.The advanced query formulation used for GM1 detection(ts=GM1 not ts=gangliosidosis)or ts=monosialoganglioside or ts=Ganglioside not(ts=Gangliosidosis or ts=trisialo-ganglioside or ts=disialo-ganglioside or ts=GDl or ts=GD2 or ts=GD3 or ts=GT or ts=GQ1b)a
33、nd ts=(detection or colloidal gold or high performance liquid chromatography or HPLC).The analysis combined Web of Science data and Xu YL,et al./Neural Regeneration Research.2012;7(10):792-799.794 statistic functions in Microsoft Excel.The outcomes of all articles referring to GM1 detection were sel
34、ected and analyzed using the following measurements:(1)distribution of subject areas;(2)number of publications annually;(3)document type and language of publications;(4)distribution of institutions;(5)distribution of output in journals;(6)the number of countries in which the article is published;(7)
35、top cited paper.RESULTS Distribution of subject areas of GM1 detection included in Web of Science during 2002 and 2011 Based on the classification of subject areas on Web of Science,the article output data was grouped into 250 subject categories.The articles of the top 10 related subject categories
36、in the research were analyzed in Table 1.From Table 1,the distribution of subject categories showed that most studies on GM1 detection were related to the biochemistry molecular biology and neurosciences.Moreover,Immunology and cell biology were found in the top five subject categories.Annual public
37、ation output on GM1 detection in Web of Science between 2002 and 2011(Figure 1)The publication on GM1 detection keeps stable between 2002 and 2011.The publication on GM1 detection reached a peak in 2004.However,there are a number of years which saw slightly drops in the number of paper published dur
38、ing 2005 and 2009.Document type and language of publications in Web of Science between 2002 and 2011 The distribution of document types identified by the SCI-E was analyzed.Eight document types were found in 1 880 publications from 2002 to 2011.Articles(1 599,85.05%)were the most frequently used doc
39、ument type,followed by meeting abstracts(115;6.12%),and reviews(112;5.96%).The correction was excluded from the analysis due to less academic significance(Table 2).Ninety-seven percent of all these journal articles were published in English.Articles were also published in French(17;0.90%),German(8;0
40、.43%),Unspecified(7;0.37%),Russian(6;0.32%),Spanish(4;0.21%),Japanese(4;0.21%),Czech(1;0.05%).Garfield et al 14 reported that English is the main language of microbiology research,accounting for 90-95%of all the SCI papers.English remains the dominant language as it is the main language in many fiel
41、ds15-16.This is expected because most of the journals listed in the ISI are published in English17.Distribution of institutions of GM1 detection included in Web of Science during 2002 and 2011(Table 3)1781752221621881992001751931880501001502002502002200320042005200620072008200920102011Publication ye
42、arNumber of literatureFigure 1 The distribution of annual publication output of monosialoganglioside detection.Table 3 Distribution of top 10 institutions publishing articles referring to monosialoganglioside from 2002 to 2011 Rank Institution Country No.of papers%of total publication 1 University o
43、f Milan Italy 53 2.82 2 Nagoya University Japan 40 2.13 3 Kinki University Japan 36 1.92 4 Dokkyo University Japan 31 1.65 5 Russian Academy of Sciences Russia 31 1.65 6 Chiba University Japan 30 1.60 7 Kyoto University Japan 30 1.60 8 Medical College of Georgia United States 30 1.60 9 National Rese
44、arch Council Canada Canada 30 1.60 10 University of Medicine and Dentistry of New Jersey United States 28 1.49 Table 1 Publication output of monosialoganglioside de-tection in the top 10 subject categories from 2002 to 2011 Rank Subject category No.of pa-pers%of total publication 1 Biochemistry mole
45、cular biology 520 27.66 2 Neurosciences 394 20.96 3 Clinical neurology 269 14.31 4 Immunology 229 12.18 5 Cell biology 173 9.20 6 Biophysics 162 8.62 7 Pharmacology pharmacy 80 4.26 8 Chemistry physical 76 4.04 9 Microbiology 71 3.78 10 Chemistry multidisciplinary 62 3.30 Table 2 Main document type
46、of publication output of monosialoganglioside detection from 2002 to 2011 Document type No.of papers%of total publication Article 1 599 85.05 Meeting abstract 115 6.12 Review 112 5.96 Proceedings paper 74 3.94 Editorial material 20 1.06 Letter 14 0.75 Correction 2 0.11 Book chapter 1 0.05 No.of pape
47、rs Xu YL,et al./Neural Regeneration Research.2012;7(10):792-799.795 The distribution of institutions for most studies on GM1 detection was Japan and United States.It is interesting that,though USA published 29.73%of articles on GM1 detection,the top one institution is in Italy and the tops two to fo
48、ur institutions are in Japan.The top three cited papers published by University of Milan are as follows:Authors:Sonnino S,Mauri L,Chigorno V,et al.Source journal:Glycobiology.Publication year:2007.Title:Gangliosides as components of lipid membrane domains18.Total citations:73.Average annual citation
49、s:12.17.Authors:Terraneo G,Potenza D,Canales A,et al.Source journal:Journal of the American Chemical Society.Publication year:2007.Title:A simple model system for the study of carbohydrate-aromatic interactions19.Total citations:54.Average annual citations:9.00.Authors:Papini N,Anastasia L,Tringali
50、C,et al.Source journal:Journal of Biological Chemistry.Publication year:2004.Title:The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions20.Total citations:61.Average annual citations:6.78.Distributio