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1、 V. Preparation of suppositories采用熔融法制备空白甘油栓和醋酸洗必泰栓剂。Purposes1. To know the characters and applications of the bases of suppositoroes.2. To master the characters and applications of fusion method to prepare suppositories.Equipments and materials1. EquipmentsMold of vaginal suppository, evaporating d
2、ish, water bath, ice bath, electric stove, analytical balance, disintegration determination apparatus, etc.2. MaterialsGlycerol, gelatin, stearic acid, sodium carbonate, tannic acid, chlorhexide acetate, borneol, citric acid, liquid paraffin, etc.Procedures1. Glycerol suppository(1) FormulationGlyce
3、rol 8gSodium carbonate 0.2gStearic acid 0.8gDistilled water 1g(2) PreparationSodium carbonate, distilled water and glycerol is mixed in the evaporating dish above the water bath. Add stearic acid slowly into this evaporating dish in the agitation. Then pour this solution into the molds of rectal sup
4、pository smeared with liquid paraffin when the mixture turns into settled solution. After they are cooled, scrape off the unnecessary parts, and the final products can be got.2. Chlorhexidini acetas suppository(1) FormulationChlorhexide acetates 0.05gTween 80 0.2gBorneol 0.01gEthanol 0.5mlGlycerol 9
5、.0gGelatin(minute grain) 2.7gDistilled water add up to 20.0gTotal sum: two pieces(2) PreparationAdd the gelatin of the formulation in evaporating dish and swell in 20ml of distilled water for 30min to make it soft. Add glycerol, and heat the mixture in water bath to make gelatin dissolved, keep heat
6、ing until the weight of mixture is 18-20g. Dissolve chlorhexide acetate in tween 80 and borneol in ethanol respectively, mix the above two solutions and add the gelatin solution prepared in the agitation. Pour this mixture into the molds of vaginal suppository smeared with liquid paraffin immediatel
7、y. After they are cooled, scrape off the unnecessary parts. The final products can be got.3. Evaluation or determination of suppository(1) Weight variation(2) The time limit of meltingQuestions1. What are the principles of preparation and precautions in the preparation of glycerol suppository?2. What is the mechanism of action of glycerol suppository?3. What is the meaning of displacement value according to the experiment?4. What are the characteristic of glycerin-gelatin base in suppositories?