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1、专业英语一、课程简介生物信息学是融合生命科学与数理科学的新兴学科,是一门研究生物和生物相关系统中信息 内容与信息流向的综合系统科学。生物信息学专业英语课程,作为一门交叉新兴学科的学习基础 课程,其主要教学目的有三:一是使学生掌握一定量的专业词汇,能够阅读生物信息学专业英文 教材和专业文献;二是能较准确和熟练的运用英文撰写本专业毕业论文的英文摘要;三是为后续 专也课程的双语教学打下专业词汇的基础。通过本课程的学习,使学生掌握专业英语的特点及翻译技巧,专业论文的阅读及写作方法, 扩大科技词汇量,以便能准确、迅速的了解国外科技开展动态,加强对外交流能力。二、理论教学内容1 .听力训练内容:摘选自Na
2、tional Institutes of Health (NIH) Podcast中有关生物学、医学、生物信息学 的短篇科技新闻报道,共40篇。A Low Calorie Diet May Affect AgingExercise May Reduce Breast Cancer RiskMaking Multiple Lifestyle Changes Beneficial in Lowering High Blood PressureOsteoporosis Drug Shown to Protect Older Women from Breast CancerNHLBI Adds New
3、 Resources on Heart HealthBy Continuing Medication, Older Adults Reduce Chances of Further Depressive EpisodesNew Treatment Strategies Help Depressed Patients Become Symptom FreeNEI Shows Most Have Good Vision, but 14 Million Americans are Visually ImpairedHigh Doses of Experimental Bird Flu Vaccine
4、 Induce Immune Responses in Adults Black, White Teens Show Differences in Nicotine MetabolismThe Future of Medical Imaging: Transforming Health CareStudy Links Diet with Alcohol Drinking PatternsSpouses Hospitalization Increases Partners Risk of Death, Study ShowsStudy Indicates Dietary Supplement P
5、rovides Pain Relief to SomeElderly Have Higher Risk of Cardiovascular, Respiratory Disease from Fine Particle PollutionNCI Seeks to Identify Potential Genetic Factors for Breast and Prostate CancerNIA Arts Program Aims at Debunking Myths of AgingNIA Report Shows Changes in Aging TrendsHaving a Sibli
6、ng with Heart Disease Raises Personal RiskAir Pollution, High Fat Diet, Leads to Atherosclerosis in MiceMost Behaviors Leading to Major Causes of Preventable Death Have Begun by Young AdulthoodInitial Results Help Clinicians Identify Patients with Treatment-Resistant DepressionComponent in Soy Produ
7、cts Causes Reproductive Problems in Lab MiceNobelist Discovers Antidepressant Protein in Mouse BrainNHLBI NIDDK Issue Statement on NIH Research Into Obesity and Type 2 DiabetesNIH Funds Largest Long-Term Study of Health and Disease in Hispanic PopulationsBehaviors May Indicate Risk of Adolescent Dep
8、ressionIts Never Too Early to Prevent DiabetesEarly Teen Drinkers at Higher Risk for Alcoholism107One Third of Diabetes Sufferers Unaware of Having the DiseaseResearchers Gain Insight Into Why Brain Areas Fail to Work Together in AutismStudy Shows Childen of Smoking Mothers Exhibit Early Behavior Pr
9、oblemsChemical in Air Fresheners, Other Household Products, May Reduce Lung FunctionScientists Identify Gene That Strongly Affects Risk for Most Common Form of Melanoma25th Anniversary of First Reported Cases of AIDSLow Income Older Americans Have More Physical Limitations Than Wealthier PeersNIH Re
10、leases Three New Curriculum Supplements掌握内容:掌握专业词汇;具备能够从报道中理解具体或整体信息的能力。了解内容:了解科研汇报讲座的基本表达方式。2.阅读理解及翻译内容:第一阶段:使用摘自美国科学网( : / scientificamerican /)的短片科学研究报道 或新闻(共30篇)进行初级阅读理解与翻译训练。Youve got to find what you love, Jobs saysThe chimpanzee genome is unveiledGenes decide if coffee hurts or helps your hea
11、rtGenes Predict Body Shape and FatnessGenetics may put some at higher risk for bird flu, expert saysHuge protein-interaction database could save livesGene mutation boosts cancer risk in men Study:Optimists Live LongerStay Up Late and See Something OddUS tests may miss breast cancer genes*Loneliness
12、Kills, Study ShowsDarwins Natural Selection Still at Work in HumansNegative selectionNew Breast Cancer Gene FoundWho let the dogs out? a genetic classification of dog breedsThe Gene That Made Us HumanStudy: Laughter Really Is ContagiousDont Laugh: Just Think About ItNo Joke: Animals Laugh, TooNot Fu
13、nny, But LOL AnywayBrain Tumors May be InfectiousGlobal Warming Affects Space Station OrbitAfter Lung Cancer Surgery, Nearly Half of Patients Resume SmokingNew Data Show Global Warming Kills Marine LifeCats Get AlzhcimcfsHow to Handle Holiday StressReport: CO2 Emissions Double Since 1990sVideo Game
14、Violence Goes Straight to Kids* HeadsStudy Disputes Cell Phone-Cancer Link第二阶段:中等难度的生物信息学题材文章,主要为教材Bioinformatics(影印本)。108Section A-Overview of bioinformaticsAl The scoe of bioinformaticsA2 Bioinformatics and the InternetA3 Useful bioinformatics sites on the WWWSection B- Data acquisitionB1 Sequenci
15、ng DNA, RNA and proteinsB2 Determination of protein structureB3 Gene and protein expression dataB4 Protein interaction dataSection C-Databases-contents, structure and annotationC1 File formatsC2 Annotated sequence databasesC3 Genome and organism-specific databasesC4 Miscellaneous databasesSection D-
16、Retrieval of biological dataDI Data retrieval with Entrez and DBGET/LinkDBD2 Data retrieval with SRS (sequence retrieval system)Section E-Searching sequence databases by sequenceEl Sequence similarity searchesE2 Amino acid substitution matricesE3 Databases searches: FASTA and BLASTE4 Sequence filter
17、sE5 Iterative database searches and PSI-BLASTSection F-Multiple sequence alignment and family relationshipsFl Multiple sequence alignment and family relationshipsF2 Protein families and pattern databasesF3 Protein domain familiesSection G-PhylogeneticsG1 Phylogenetics, cladistics and ontologyG2 Buil
18、ding phylogenetic treesG3 Evolution of macromolecular sequencesSection H-Sequence annotationHl Principles of genome annotationH2 Annotation tools and resourcesSection I-Structural bioinformaticsIl Conceptual models of protein structure12 The relationship of protein three-dimensional structure to pro
19、tein function13 The evolution of protein structure and function14 Obtaining, viewing and analyzing structural data15 Structural alignment16 Classification of proteins of known three-dimensional structure: CATH and SCOP17 Introduction to protein structure prediction18 Structure prediction by comparat
20、ive modeling19 Secondary structure prediction109IIO Adnanced protein structure prediction and prediction strategiesSection J-Microarray data analysisJI Microarray data: analysis methodsJ2 Microarray data: tools and resourcesJ3 Sequence sampling and SAGE掌握内容:掌握约300-500专业词汇;基本准确进行专业知识的英汉互译。了解内容:能够阅读初级
21、难度的生物信息学专业英文资料和专业文献。3 .专题科技文献阅读训练内容:进行三个专题的科技文献阅读专题一: Human Genome CollectionIt is now more than 15 years since work began sequencing the 2.85 billion nucleotides of the human genome.While the draft sequence was published in Nature in 2001, researchers at the Human Genome Project continued to fill t
22、he gaps and subject individual chromosomes to ever more detailed analyses.The draft sequences : Comparing speciesInitial sequencing and analysis of the human genomeMining the draft human genome专题二:表达谱秩序分析专题Classifying Gene Expression Profiles from Pairwise mRNA ComparisonsSimple decision rules for c
23、lassifying human cancers from gene expression profilesLarge-scale integration of cancer microarray data identifies a robust common cancer signatureAccurate Molecular Classification of Kidney Cancer Subtypes Using MicroRNA SignatureRank products : a simple, yet powerful, new method to detect differen
24、tially regulated genesin replicated microarray experiments专题三:不同类型英文文献的阅读技巧软件类:LiC, LiX, Miao Y, Wang Q, Jiang W, et al. (2009) SubpathwayMiner: a software package for flexible identification of pathways.Nucleic Acids Res 37: el31.综述类:Oti M, Brunner HG (2007) The modular nature of genetic diseases.C
25、lin Genet 71: 1-11.分析类:Yildirim MA, Goh KL Cusick ME, Barabasi AL, Vidal M (2007) Drug-target network.Nat Biotechnol 25: 1119-1126.掌握内容:掌握各专题内的专业英语词汇;了解科技文献的结构特点;具备能够独立的理解 一篇完整的科技文献的能力。了解内容:通过学习能够阅读专业科研论文,把握科研论文的背景和创新点,能够初步了解 本专业的科研新动态,在学习英语的同时,也能够体会生物信息科研思想。4,应用写作及口语专题训练(应用能力训练)内容:进行三个专题课程:Presenta
26、tion (How to create a good presentation-some rules)Job (interview English- How to response to an English interview and How to make your resume)Research (How to Do Research From literatures to Articles)如何制作英文简历及推荐信;如何入手阅读英文文献及进行简单科的技摘要写作。掌握内容:从演讲,工作,科研三个方向学习一些专业英语相关的技能,学习如何用英语流110 利进行专业相关知识的介绍,并用英文完成
27、一个高质量专业相关课题演讲;能就专业领域的话题 和提纲撰写短文,表达意思清楚,用词准确,符合专业论文的写作风格和习惯。了解内容:通过学习能够制作英文简历及推荐信;了解阅读英文文献及进行简单科的技摘要 写作。5 专业英语论文写作训练掌握内容:掌握英语科技论文abstract、introduction的构成要点,掌握相应局部的写作句式、 词汇。能够完成学位论文英文摘要的写作。了解内容:了解英语科研论文的组成要素,学习各个要素的写作要素,能够完成学位论文英 文摘要的写作。三、参考资料L参考书Bioinformatics 内部编写生物信息学-Bioinformatics (影印本).D.R.韦斯特海德、J.H帕里什、R.M.特怀曼著.科 学出版社.2004年9月出版生物专业英语(第4版).蒋悟生编.高等教育出版社(十一五规划教材).2016-05-012 .网络资源NIH PODCAST ()cell biology ()四、学时分配序号教学内容参考学时总学时理论学时实验学时1听力训练151502阅读理解及翻译(第一阶段20,第二阶段28)484803专题科技文献阅读训练(每个专题10)303004应用写作及口语专题训练121205专业英语论文写作训练15150合计1201200111