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1、论论 文文 题题 目目：PharmacokineticPharmacokinetic andand pharmacodynamicpharmacodynamic studiesstudies onon thetheantivirus effects of A(antivirus effects of A(一种中草药一种中草药)against virus B)against virus B（一种病毒）（一种病毒）所投杂志：Life Sciences投稿结果：这次大修后又经过一次小修，被接受发表编辑信内容（注：有删节）：Dear Mr.XXX,Your manuscript has been ex
2、amined by the editors and qualifiedreferee.We think the manuscript has merit but requires revision beforewe can accept it for publication in the Journal.Careful considerationmust be given to the points raised in the reviewer comments,which areenclosed below.If you choose to submit a revision of your
3、 manuscript,pleaseincorporate responses to the reviewer comments into the revised paper.A complete rebuttal with no manuscript alterations is usually consideredinadequate and may result in lengthy re-review procedures.A letter detailing your revisions point-by-point must accompany theresubmission.Yo
4、u will be requested to upload this Response to Reviewers as aseparate file in the Attach Files area.We ask that you resubmit your manuscript within 45 days.After thistime,your file will be placed on inactive status and a further submissionwill be considered a new manuscript.To submit a revision,go t
5、o and log in as an Author.You will see a menu item called Submission Needing Revision.You willfind your submission record there.Yours sincerely,Joseph J.Bahl,PhDEditorLife Sciences，Format Suggestion:Please access the Guide to Authors at our websiteto check the format of your article.Pay particular a
6、ttention to ourReferences style.Reviewers comments:Reviewer#1:XXXXX（略）Reviewer#2:XXXXX（略）Editors note and suggestions:（注：编辑的建议）Title:Re-write the title to read more smoothly in contemporaryEnglishPharmacokinetic and pharmacodynamic studies of the antiviral effectsof A against virus B.Abstract:Re-wri
7、te the abstract to read more smoothly.A,an alkaloid isolated from C(注：一种中草药),was tested forantiviral activity against virus B.Both in vitro and in vivo assays alongwith serum pharmacological experiments showed A to have potent antiviralactivity.The pharmacokinetic profile of A in Sprague/Dawley rat
8、plasmaafter oral administration was measured by HPLC.Blood samples taken atselected time points were analyzed to study potential changes in antiviralpharmacodynamicsasmeasuredbyinfectivityofviruses.Fromthesimilarity of the serum concentration profiles and antiviral activityprofiles it is concluded t
9、hat A it self,rather than a metabolite,exertedthe effect against the virus prior to bioinactivation.The need foreffective clinical agents against virus B and these results suggest thepossibility of benefit from further experiments with A.The authors should check to be sure that the terms blood sampl
10、es,plasma and serum are always used appropriately throughout the abstractand text.Introduction:some sentences can be made less passive.example 1stparagraph A appears to be the most important alkaloid isolated from theplant,its structural formula is shown in Fig 1.While it produceda general inhibitio
11、n of antibody production lymphocyte proliferation wasstimulated(Xia and Wang,1997).These pharmacological properties suggesta potential use in the treatment of viral myocarditis against virus B thatcould be studied in experiments in cell culture and animals.The authors should check the entire manuscr
12、ipt for spelling errors(example given:in your text alkaloid is incorrectly spelled alkaloid)The authors should read the guidelines to the authors and notinclude the first name of the authors being cited in the text.In thereference section the first name should be abbreviated as shown in theguideline
13、 to authors(thus the earlier text reference should be(Liu etal.,2003)and the remaining one should be(Chen et al.,2002)。The authors instead of directly answering the first complexquestion of reviewer#1 may include the three questions as future researchaim in the discussion section.Rather than redrawi
14、ng figure the authors may choose to amendthe wording of the statistical analysis section to state that the resultof tables are means+-SEM and for figures are+-SD.reviewer#1 comment number 8 and reviewer#2 comment 3 mightbe satisfied by inclusion of a representative photo of cells and heartshowing CP
15、E.Remember most readers of the journal have never seen whatyou are trying to describe.Because I think that you can deal with all of the points raised I amhoping to see a revised manuscript that you have carefully checked forerrors.If you have questions or do not know how to respond to any of thepoin
16、ts raised please contact me at Joseph Bahl,PhD Editor 2 Life Sciences作者回复信原稿：Dear Dr.Bahl,Im（注：正式信函不要简写）very appreciate（注：不适合作为给编辑回信的开始，同时有语法错误）for your comments and suggestions.I（注：实际上是学生做的）have conducted in vivo antivirus experimentsagain（注：要表明是应审稿人或编辑建议而作）.Mice were sacrificed on 15days and 30 da
17、ys after infection.Death rate,heart weight to body weightratio(HW/BW),virus titers and pathologic slices（注：用词错误）werecalculated（注：用词不当）.Production of mRNA of IL-10,IFN-and TNF-were（注：语法错误）measured by RT-PCR.|I have revised this manuscript and especially paid much attention toyour comments and suggest
18、ions.I would like to re-submit it to LIFE SCIENCE.Title of manuscript has been changed to“The antivirus effects of Aagainst virus B and its phar macokinetic behaviour in SD rats serum”tomake it more clear and smooth.Answers to Reviewers questions were as follows:（注：可附在给编辑的回复信后）Reviewer#1:XXXXXReview
19、er#2:XXXXXEditors note and suggestions:Title:Re-write the title to read more smoothly in contemporaryEnglish(Answer:I have rewrite the title to“The antivirus effects of Aagainst virus B and its pharmacokinetic behaviour in SD rats serum”tomake it more clear and smooth（注：多处语法错误）.Abstract:Re-write the
20、 abstract to read more smoothly.Answer:I have revise the abstract carefully to make it more smoothand informative（注：语法错误）.The authors should check to be sure that the terms blood samples,plasma and serum are always used appropriately throughout the abstractand text.Answer:I have paid attention to th
21、is question and it is clearer（注：不具体）.Introduction:some sentences can be made less passive.Answer:I have revise the whole paper to make sentences less passiveand obtained help of my colleague proficient in English（注：语法错误，句子不通顺）.The authors should check the entire manuscript for spelling errorsAnswer:
22、Im very sorry to give you so much trouble for those spellingerrors（注：不必道歉，按建议修改即可）.I have carefully corrected them.The authors should read the guidelines to the authors and not includethe first name of the authors being cited in the text.In the referencesection the first name should be abbreviated a
23、s shown in the guidelineto authors(thus the earliertext reference should be(Liu et al.,2003)and the remaining one should be(Chen et al.,2002)Answer:I changed the style of references.Rather than redrawing figure the authors may choose to amend thewording of the statistical analysis section to state t
24、hat the result oftables are means+-SEM and for figures are+-SD.Answer:（注：作者请编辑公司帮回答）reviewer#1 comment number 8 and reviewer#2 comment 3 might besatisfied by inclusion of a representative photo of cells and heartshowing CPE.Remember:most readers of the journal have never seen whatyou are trying to d
25、escribe.Answer:Thank you for your suggestions.I have supplemented picturesof cardiac pathologic slices in the paper(Fig2).&I have to apologize for giving you so much trouble because of thosemisspelling and confusing statements（注：一般不是延误或人为失误，不必轻易道歉，按建议修改即可）.Your comments and suggestions really helped
26、me a lot.I have put great efforts to this review.I wish it can besatisfactory.If theres（注：正式信函不要简写）any information I can provide,please dont hesitate to contact me.Thank you again for your time and patience.Look forward to hear（注：语法错误）from you.Yours SincerelyXxxx Xxxx(通讯作者名)建议修改稿：Dear Dr.Bahl,Thanks
27、 you very much for your comments and suggestions.As suggested,we have conducted in vivo antivirus experiments.Micewere sacrificed on 15 days and 30 days after infection with virus B.Mortality,heart weight to body weight ratio(HW/BW),virus titers andpathologic scores were determined.In addition,mRNA
28、expression of IL-10,IFN-and TNF-were measured by RT-PCR.We have revised the manuscript,according to the comments andsuggestions of reviewers and editor,and responded,point by point to,thecommentsaslistedbelow.Sincethepaperhasbeenrevisedsignificantly throughout the text,we feel it is better not to hi
29、ghlightthe amendments in the revised manuscript（正常情况最好表明修改处）.The revised manuscript has been edited and proofread by a medicalediting company in Hong Kong.I would like to re-submit this revised manuscript to Life Sciences,and hope it is acceptable for publication in the journal.Looking forward to he
30、aring from you soon.With kindest regards,Yours SincerelyXxxx Xxxx(通讯作者名)?Replies to Reviewers and EditorFirst of all,we thank both reviewers and editor for their positiveand constructive comments and suggestions.Replies to Reviewer#1:Xxxxx（略）Replies to Reviewer#2:Xxxxx（略）Replies to the Editors note
31、and suggestions:Title:Re-write the title to read more smoothly in contmeporaryEnglish、Answer:I have rewrite the title to“The antivirus effects ofSophoridine against Coxsackievirus B3 and its pharmacokinetics in rats”to make it more clear and read more smoothly.Abstract:Re-write the abstract to read
32、more smoothly.Answer:I have rewritten the abstract to make it more informative andread more smoothly.The authors should check to be sure that the terms blood samples,plasma and serum are always used appropriately throughout the abstractand text.Answer:I have paid attention to this issue,and they are
33、 now usedappropriately throughout the abstract and text in the revised manuscript.Introduction:some sentences can be made less passive.Answer:I have revised the whole paper to make sentences less passivewith the help of the editing company.The authors should check the entire manuscript for spelling
34、errorsAnswer:This has been done by us as well as the editing company.The authors should read the guidelines to the authors and not includethe first name of the authors being cited in the text.In the referencesection the first name should be abbreviated as shown in the guidelineto authors(thus the ea
35、rliertext reference should be(Liu et al.,2003)and the remaining one should be(Chen et al.,2002)Answer:I have changed the style of references according to thejournal.Rather than redrawing figure the authors may choose to ament thewording of the statistical analysis section to state that the result of
36、tables aremeans+-SEM and for figures are+-SD.Answer:SD has been used throughout the text,and shown in the Figs.3 and 4 in the revised manuscript.reviewer#1 comment number 8 and reviewer#2 comment 3 might besatified by inclusion of a representative photo of cells and heart showingCPE.Remember:most re
37、aders of the journal have never seen what you aretrying to describe.Answer:Thank you very much for the suggestion.I have added picturesof cardiac pathologic changes in the revised manuscript(Fig.2).论文题目：Clinical implications of XXXX(一种病理指标)in X cancer%所投杂志：所投杂志：BMC Cancer.BMC Cancer.结果：这次大修后被接受发表（同时
38、编辑在接受信中提出课题是否得到伦结果：这次大修后被接受发表（同时编辑在接受信中提出课题是否得到伦理委员会同意的问题。作者在论文适当地方加上了有关陈述）理委员会同意的问题。作者在论文适当地方加上了有关陈述）审稿人内容（有删节）：Reviewers reportClinical implications of XXXX(一种病理指标)in X cancerVersion:1 Date:12 June 200XReviewer:XXXX XXXX(A Japanese Reviewer)Reviewers report:。General-Major Compulsory Revisions(that
39、 the author must respond to beforea decision on publication can be reached)1.XXXXX.2.XXXXX.3.XXXXX.4)The clinico pathological parameters examined are reported in Table1.Among the primary tumor characteristics,the Authors consider thediameter,but ignore T stage.Consequently the T parameter is notcons
40、idered in the multivariate analysis.In other studies,T stage hasemerged as an independent factor.The Authors should therefore state thereason for their unusual choice.Nor is the number of metastatic nodesreported in this table.Moreover,for tumor differentiation,the Authorsdistinguish between two gro
41、ups(differentiated vs undifferentiated),instead of between the usual 3 categories(G1,G2 and G3).I have neverheard of the histological classification used by the Authors(massive,next and diffuse).They might therefore state their reasons for choosingit,providing a reference,if available.-Minor Essenti
42、al Revisions(such as missing labels on figures,or thewrong use of a term,which the author can be trusted to correct)XXXXX.-Discretionary Revisions(which the author can choose to ignore)(None)What next:Reject because too small an advance to publishLevel of interest:An article of limited interestQuali
43、ty of written English:Needs some language corrections beforebeing publishedbStatistical review:Yes,but I do not feel adequately qualifiedto assess the statistics.作者原答:T stage is considered in the multivariate analysis,and somemodification has been made in tumor differentiation and histologicalclassi
44、fication.建议改答：We accept Dr.XXX comment(表明你对审稿人的欣赏和赞同).In the revised version of the manuscript,T stage has been added in themultivariate analysis,and description of tumor differentiation andhistologicalclassificationhasbeenmodified;thehistologicalclassification in the original manuscript has been re
45、placed by thegenerally accepted classification(Page 6,line 15;Table 4)(同意审稿人的建议，并根据其建议进行修改。同时指出在何处做了修改。).加注：作者原回答与修改后的回答并无本质差别，正文中的修改也是一样的。但作者原回答会给审稿人“不太乐意”或“轻描淡写”的印象。因为审稿人花了122 个单词来就此问题发表建议，而作者只用了 20 个。修改后的回答，相信一开始就赢得审稿人的好感。你的回答不光是给审稿人看的，杂志编辑也会看（至少审稿人会这么认为），所以，审稿人会有种满足感（国外审稿人没有酬劳，得到作者和编辑的认可是他们审稿最主要
46、的目的）。建议得到认可（当然，这里审稿人的确是正确合理的），而且作者还按其建议对文章进行修改，相信绝大多数审稿人是不会（不好意思）再拒绝修改稿的（所谓伸手不打笑面人）。当然，这篇文章起死回生、二审通过审稿关，关键是杂志编辑手下留情，给了作者再投(Re-submission)的机会。有时，审稿人的建议得到作者认可，但作者无法按建议修改，尤其补做试验。这种情况将在以后举例说明。论文题目：Misdiagnosis of A(一种先天性疾病)as 某某 tumor:a case report所投杂志：所投杂志：Neuro-OphthalmologyNeuro-Ophthalmology投稿结果：大修，
47、结果未知（前途未卜，因为该审稿人建议拒稿，但审稿投稿结果：大修，结果未知（前途未卜，因为该审稿人建议拒稿，但审稿人给作者机会）人给作者机会）。审稿人审稿内容及作者原答和建议改答（有删节）：Reviewer 2s report审稿人问题 1The authors try to caution eye specialists and neurosurgeons not todo major orbital surgery on children without doing a dilated fundusexamination with an indirect ophthalmoscope.In
48、their case,once thecorrect diagnosis was made,by properly examining the eye,surgery wasnot necessary.A thorough pre-operative examination of the eye should bea automatic prerequisiteto orbital surgery forpoor vision,so I do notthink their paper presents a unique idea.作者原答Answer:Althoughcorrectdiagno
49、siscanbemadebythoroughexaminations,doctors are often misleaded by a“wrong”chief complaint（wrong 可能表示主诉症状本身误导，也可能表示病人说错，也可能是收诊医生记录错误）.In our case,the retinal specialist who made a misdiagnosisat first（at first 用词不当）,was misleaded by“blurred vision in theleft eye over a month”and did not pay enough at
50、tention to differentiatea congenital disease from“tumor”（需说明两者关联）.In（On）the otherhand,it is also the result of too many patients we have to manage perworking day(most large hospital（hospitals）in China is(are)on thisoccasion)and doctors in outpatient clinic have not much time to performthorough ophth