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1、有机合成Organic Synthesis办公地址:化学楼617参考书1、有机合成设计斯图尔特.沃伦 著(英)丁新腾,林子森 译2、有机合成 斯图尔特.沃伦 著(英)丁新腾 译3、Advanced Organic Chemistry D.A.Evans有有机机合合成成导导论论1、有有机机合合成成的意义的意义 人类最基本的需求:人类最基本的需求:生存生存(食品(食品-农药)农药)人类最高级的渴望:人类最高级的渴望:长寿长寿(疾病(疾病-医药)医药)2、导导论论之含义之含义有机合成是一门艺术。分子有机合成是一门艺术。分子建筑。风格建筑。风格-Preparation of Alkane-1.Hydr
2、ogenation of Alkenes2.Reduction of Alkyl Halides3.Coupling of Alkyl Halides with Organometalic Compounds-Preparation of Alkene-1.Dehydrohalogenation of Alkyl Halide2.Dehydration of Alcohols3.Dehalogenation of Vicinal Dihalides4.Reduction of Alkynes-Preparation of Alcohol-1.Oxymercuration-Demercurati
3、on2.Hydroboration-Oxidation3.Grignard Synthesis4.Hydrolysis of Alkyl Halides5.Hydroxylation of Alkenes-Preparation of Halide-Preparation of Ether-1.Williamson Synthesis2.Alkoxymercuration-Demercuration-Preparation of Ether-Preparation of Alkylbenzene-1.Friedel-Crafts Alkylation2.Conversion of Side C
4、hain-Preparation of Alkylbenzene-Preparation of Phenol-Preparation of Amine-Reaction of Diazonium-1.Replacement of Nitrogen2.Coupling-Reaction of Diazonium-Preparation of Aldehyde&Ketone-1.Oxidation of Primary Alcohols2.Oxidation of Methylbenzene3.Reduction of Acid chlorideAldehydeKetone1.Oxidation
5、of Secondary Alcohols2.Friedel-Crafts Acylation-Preparation of Aldehyde&Ketone-Reactions of Aldehyde&Ketone-1.Oxidation2.Reduction3.Addition of Cyanide4.Addition Derivatives of ammonia5.Addition of Alcohols6.Cannizzaro Reaction7.Addition of Grignard Reagent-Reactions of Aldehyde&Ketone-Reaction of C
6、arbanion-1.Halogenation of ketones2.Nucleophilic Additon to Carbonyl Compounds3.Nucleophilic Acyl Substitution-Reaction of Carbanion-Substitution on Aromatic Ring-1.Nitration2.Sulfonation3.Halogenation4.Friedel-Crafts Alkylation5.Friedel-Crafts Acylation6.Protonation-Substitution on Aromatic Ring-Preparation of Acid-1.Oxidation of Primary Alcohols2.Oxidation of Alkylbenzene3.Carbonation of Grignard Reagent4.Hydrolysis of Nitriles-Preparation of Acid-