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1、MitochondrialFission,Fusion,andStress|ScienceMitochondrialDynamicsMitochondriathepowerhousesofthecellareautonomousorganelleswiththeirowngenomes.Withincells,mitochondriaareremarkablydynamic,continuallymovingaroundthecytoplasmandundergoingfusionandfissionreactions.YouleandvanderBliek(p.)reviewtheimpor
2、tanceofmitochondrialfusionandfissionincellularresponsestostress,interferencewithwhicharelikelytoplayanimportantroleinavarietyofdiseasesincludingParkinsonsdisease.IntheirPerspective,explainthattheendoplasmicreticulumisanactiveparticipantinmitochondrialdivisionanddiscusshowmitochondrialdynamicsandcell
3、deatharelinked.AbstractMitochondrialfissionandfusionplaycriticalrolesinmaintainingfunctionalmitochondriawhencellsexperiencemetabolicorenvironmentalstresses.Fusionhelpsmitigatestressbymixingthecontentsofpartiallydamagedmitochondriaasaformofcomplementation.Fissionisneededtocreatenewmitochondria,butita
4、lsocontributestoqualitycontrolbyenablingtheremovalofdamagedmitochondriaandcanfacilitateapoptosisduringhighlevelsofcellularstress.Disruptionsintheseprocessesaffectnormaldevelopment,andtheyhavebeenimplicatedinneurodegenerativediseases,suchasParkinsons.GetfullaccesstothisarticleViewallavailablepurchase
5、optionsandgetfullaccesstothisarticle.ALREADYASUBSCRIBERORAAASMEMBER?SigninasanorviayourReferencesandNotes1HoppinsS.,LacknerL.,NunnariJ.,Themachinesthatdivideandfusemitochondria.Annu.Rev.Biochem.76,751(2007).10.1146/annurev.biochem.76.071905.0900482ElgassK.,PakayJ.,RyanM.T.,PalmerC.S.,Recentadvancesi
6、ntotheunderstandingofmitochondrialfission.Biochim.Biophys.Acta,publishedonline10May2020.225800413FriedmanJ.R.,etal.,ERtubulesmarksitesofmitochondrialdivision.Science334,358(2018);10.1126/science.1207385.10.1126/science.12073854ChenH.,ChanD.C.,Physiologicalfunctionsofmitochondrialfusion.Ann.N.Y.Acad.
7、Sci.1201,21(2018).10.1111/j.1749-6632.2018.05615.x5ChenH.,ChomynA.,ChanD.C.,Disruptionoffusionresultsinmitochondrialheterogeneityanddysfunction.J.Biol.Chem.280,26185(2005).10.1074/jbc.M5030622006SchonE.A.,GilkersonR.W.,FunctionalcomplementationofmitochondrialDNAs:Mobilizingmitochondrialgeneticsagain
8、stdysfunction.Biochim.Biophys.Acta1800,245(2018).10.1016/j.bbagen.2018.07.0077YonedaM.,MiyatakeT.,AttardiG.,Complementationofmutantandwild-typehumanmitochondrialDNAscoexistingsincethemutationeventandlackofcomplementationofDNAsintroducedseparatelyintoacellwithindistinctorganelles.Mol.Cell.Biol.14,269
9、9(1994).10.1128/MCB.14.4.26998NakadaK.,etal.,Inter-mitochondrialcomplementation:Mitochondria-specificsystempreventingmicefromexpressionofdiseasephenotypesbymutantmtDNA.Nat.Med.7,934(2001).10.1038/909769RossignolR.,etal.,Energysubstratemodulatesmitochondrialstructureandoxidativecapacityincancercells.
10、CancerRes.64,985(2004).10.1158/0008-5472.CAN-03-110110TonderaD.,etal.,SLP-2isrequiredforstress-inducedmitochondrialhyperfusion.EMBOJ.28,1589(2018).10.1038/emboj.2018.8911RamboldA.S.,KosteleckyB.,EliaN.,Lippincott-SchwartzJ.,Tubularnetworkformationprotectsmitochondriafromautophagosomaldegradationduri
11、ngnutrientstarvation.Proc.Natl.Acad.Sci.U.S.A.108,10190(2018).10.1073/pnas.110740210812GomesL.C.,DiBenedettoG.,ScorranoL.,Duringautophagymitochondriaelongate,aresparedfromdegradationandsustaincellviability.Nat.CellBiol.13,589(2018).10.1038/ncb222020BalabanR.S.,NemotoS.,FinkelT.,Mitochondria,oxidants
12、,andaging.Cell120,483(2005).10.1016/j.cell.2005.02.00114BakerM.J.,TatsutaT.,LangerT.,Qualitycontrolofmitochondrialproteostasis.ColdSpringHarborPerspect.Biol.3,a007559(2018).10.1101/cshperspect.a00755915NargundA.M.,PellegrinoM.W.,FioreseC.J.,BakerB.M.,HaynesC.M.,MitochondrialimportefficiencyofATFS-1r
13、egulatesmitochondrialUPRactivation.Science337,587(2020);10.1126/science.1223560.10.1126/science.122356016TanakaA.,etal.,Proteasomeandp97mediatemitophagyanddegradationofmitofusinsinducedbyParkin.J.CellBiol.191,1367(2018).10.1083/jcb.20180701317EganD.F.,etal.,PhosphorylationofULK1(hATG1)byAMP-activate
14、dproteinkinaseconnectsenergysensingtomitophagy.Science331,456(2018);10.1126/science.1196371.10.1126/science.119637118KomatsuM.,etal.,Impairmentofstarvation-inducedandconstitutiveautophagyinAtg7-deficientmice.J.CellBiol.169,425(2005).10.1083/jcb.20041202219TwigG.,etal.,Fissionandselectivefusiongovern
15、mitochondrialsegregationandeliminationbyautophagy.EMBOJ.27,433(2008).10.1038/sj.emboj.760196320KimI.,LemastersJ.J.,Mitophagyselectivelydegradesindividualdamagedmitochondriaafterphotoirradiation.Antioxid.RedoxSignal.14,1919(2018).10.1089/ars.2018.376821NarendraD.,TanakaA.,SuenD.F.,YouleR.J.,Parkinisr
16、ecruitedselectivelytoimpairedmitochondriaandpromotestheirautophagy.J.CellBiol.183,795(2008).10.1083/jcb.20080912522BuchetK.,GodinotC.,FunctionalF1-ATPaseessentialinmaintaininggrowthandmembranepotentialofhumanmitochondrialDNA-depletedrhodegreescells.J.Biol.Chem.273,22983(1998).10.1074/jbc.273.36.2298
17、323ValenteE.M.,etal.,Hereditaryearly-onsetParkinsonsdiseasecausedbymutationsinPINK1.Science304,1158(2004);10.1126/science.1096284.10.1126/science.109628424KitadaT.,etal.,Mutationsintheparkingenecauseautosomalrecessivejuvenileparkinsonism.Nature392,605(1998).10.1038/3341625GreeneJ.C.,etal.,Mitochondr
18、ialpathologyandapoptoticmuscledegenerationinDrosophilaparkinmutants.Proc.Natl.Acad.Sci.U.S.A.100,4078(2003).10.1073/pnas.073755610026ParkJ.,etal.,MitochondrialdysfunctioninDrosophilaPINK1mutantsiscomplementedbyparkin.Nature441,1157(2006).10.1038/nature0478827ClarkI.E.,etal.,Drosophilapink1isrequired
19、formitochondrialfunctionandinteractsgeneticallywithparkin.Nature441,1162(2006).10.1038/nature0477928PimentadeCastroI.,etal.,GeneticanalysisofmitochondrialproteinmisfoldinginDrosophilamelanogaster.CellDeathDiffer.19,1308(2020).10.1038/cdd.2020.529BurmanJ.L.,YuS.,PooleA.C.,DecalR.B.,PallanckL.,Analysi
20、sofneuralsubtypesrevealsselectivemitochondrialdysfunctionindopaminergicneuronsfromparkinmutants.Proc.Natl.Acad.Sci.U.S.A.109,10438(2020).10.1073/pnas.112068810930MeeusenS.,etal.,Mitochondrialinner-membranefusionandcristamaintenancerequiresthedynamin-relatedGTPaseMgm1.Cell127,383(2006).10.1016/j.cell
21、.2006.09.02131EhsesS.,etal.,RegulationofOPA1processingandmitochondrialfusionbym-AAAproteaseisoenzymesandOMA1.J.CellBiol.187,1023(2018).10.1083/jcb.20180608432HeadB.,GriparicL.,AmiriM.,Gandre-BabbeS.,vanderBliekA.M.,InducibleproteolyticinactivationofOPA1mediatedbytheOMA1proteaseinmammaliancells.J.Cel
22、lBiol.187,959(2018).10.1083/jcb.20180608333WangX.,etal.,PINK1andParkintargetMiroforphosphorylationanddegradationtoarrestmitochondrialmotility.Cell147,893(2018).10.1016/j.cell.2018.10.01834LindnerA.B.,MaddenR.,DemarezA.,StewartE.J.,TaddeiF.,Asymmetricsegregationofproteinaggregatesisassociatedwithcell
23、ularagingandrejuvenation.Proc.Natl.Acad.Sci.U.S.A.105,3076(2008).10.1073/pnas.070893110535FuentealbaL.C.,EiversE.,GeissertD.,TaelmanV.,DeRobertisE.M.,Asymmetricmitosis:Unequalsegregationofproteinsdestinedfordegradation.Proc.Natl.Acad.Sci.U.S.A.105,7732(2008).10.1073/pnas.080302710536JohansenT.,Lamar
24、kT.,Selectiveautophagymediatedbyautophagicadapterproteins.Autophagy7,279(2018).10.4161/auto.7.3.1448737SoubannierV.,etal.,Avesiculartransportpathwayshuttlescargofrommitochondriatolysosomes.Curr.Biol.22,135(2020).10.1016/j.cub.2018.11.05738StewartJ.B.,etal.,Strongpurifyingselectionintransmissionofmam
25、malianmitochondrialDNA.PLoSBiol.6,e10(2008).10.1371/journal.pbio.006001039FanW.,etal.,AmousemodelofmitochondrialdiseaserevealsgermlineselectionagainstseveremtDNAmutations.Science319,958(2008).10.1126/science.114778640KowaldA.,KirkwoodT.B.,Theevolutionandroleofmitochondrialfusionandfissioninagingandd
26、isease.Commun.Integr.Biol.4,627(2018).2204648241HeJ.,etal.,Mitochondrialnucleoidinteractingproteinssupportmitochondrialproteinsynthesis.NucleicAcidsRes.40,6109(2020).10.1093/nar/gks26642SuenD.F.,NorrisK.L.,YouleR.J.,Mitochondrialdynamicsandapoptosis.GenesDev.22,1577(2008).10.1101/gad.165850843Montes
27、suitS.,etal.,Membraneremodelinginducedbythedynamin-relatedproteinDrp1stimulatesBaxoligomerization.Cell142,889(2018).10.1016/j.cell.2018.08.01744AutretA.,MartinS.J.,EmergingroleformembersoftheBcl-2familyinmitochondrialmorphogenesis.Mol.Cell36,355(2018).10.1016/j.molcel.2018.10.01145GrumatiP.,etal.,Au
28、tophagyisdefectiveincollagenVImusculardystrophies,anditsreactivationrescuesmyofiberdegeneration.Nat.Med.16,1313(2018).10.1038/nm.2247SubmitaResponsetoThisArticleComposeeLetterTitle:TitleisrequiredContents:ContributorsremovecontributorFirstname:Lastname:Email:Role/occupation:affiliation:addanothercontributorStatementofCompetingInterestsCompetinginterests?YESNOPleasedescribethecompetinginterests