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1、姓名：王鹏姓名：王鹏分子病毒学和免疫学实验室分子病毒学和免疫学实验室2022/12/312022/12/311高级免疫学高级免疫学猪圆环病毒猪圆环病毒2型型ORF3蛋白的发现蛋白的发现及其在细胞毒性和致病性的研究及其在细胞毒性和致病性的研究2022/12/31高级免疫学21.introductionPorcine circovirus(PCV)was originally identified as a con-taminant of porcine kidney cell cultures(PK15).The PCV virion is icosahedral,nonenveloped,an
2、d 17nm in diameter.The genome of PCV is a single-stranded circular DNA of about 1.76 kb.PCV is classified in the genus Circovirus of the Circoviridae family,which consists of other animal circoviruses such as psittacine beak-feather disease virus,goose circovirus,canary circovirus,and pigeon circovi
3、rus.Chicken anemia virus has been assigned to the new genus Gyrovirus of this family(36),and it shares similar characteristics with the human TT virus(28,33)and TTV-like minivirus2022/12/31高级免疫学3Two genotypes of PCV have been recognized The PK15 cell-derived PCV has been considered to be non-pathoge
4、nic to pigs and is designated PCV type 1（PCV1).PCV type 2(PCV2)is now accepted as the major infectious agent involved in postweaning multisystemic wasting syndrome(PMWS),a new emerging swine disease worldwide since its occurrence in Canada in 19912022/12/31高级免疫学4PMWS primarily affects pigs between 5 and 18 weeks of age.Clinical PMWS signs include progressive weight loss,dyspnea,tachypnea,anemia,diarrhea,and jaundice.Mortality rates mayvary from 1 to 2%up to 30%in complicated cases.报告大纲Introduction安神药安神药熄风药熄风药平平肝肝药药开开窍药23412022/12/315高级免疫学