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1、Glycerol phosphate acyltransferase.Endoplasmic reticulum / Outer mitochondrial membrane. In all of biosyntheses, an activated intermediate (UDP-glucose, CDP-diacylglycerol, CDP-alcohol) is formed from a phosphorylated substrate (glucose-1-phosphate, phosphatide, phosphorylalcohol) and a nucleoside t
2、riphosphate. The activated intermediate then reacts with a hydroxyl group (the terminus of glycogen, the side chain of serine, or a diacylglycerol). Synthesis of an ether phospholipid.Synthesis of sphingolipids.Ganglioside GM1.半乳糖半乳糖唾液酸唾液酸N-N-乙酰半乳糖胺乙酰半乳糖胺葡萄糖葡萄糖Labeling of cholesterol.Fates of 3-hydr
3、oxy-3-methylglutaryl CoA.二羟甲基戊酸二羟甲基戊酸Synthesis of isopentenyl pyrophosphate.Squalene synthesis.异戊二烯异戊二烯基转移酶基转移酶焦磷酸焦磷酸牻牛儿酯牻牛儿酯Squalene cyclization.Oxidosqualene cyclase. Cholesterol formation.HMG-CoA reductase.The vesicle in liver that is releasing VLDL particle.The LDL particle (22 nm) Synthesis of bile salts.孕烯醇酮孕烯醇酮孕酮孕酮睾丸酮睾丸酮皮质醇皮质醇 皮质酮皮质酮醛固酮醛固酮雌二醇雌二醇孕烯醇酮孕烯醇酮Pathways for the formation of progesterone, cortisol, and aldosterone.孕酮孕酮Pathways for the formation for androgens and estrogens 35 结束语结束语