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1、LABOR ANALGESIA,XIANG YA HOSPITAL Dr. YAN,LABOR PAIN PATHWAYS,First stage: -pain is due primarily to uterine contractions that cause stretching and thinning of the uterine cervix. -pain impulses travel via visceral afferent fibers and enter the spinal cord at the T10 ,T11 and L1spinal segments. -pai
2、n is generally poorly localized and is dull or cramping.,LABOR PAIN PATHWAYS,Second stage: -Stretching of the perineum produces additional pain,more somatic in nature,is well localized and sharp - these impulses travel via the pudendal nerves from the S2,S3andS4spinal segments,LABOR PAIN,The amount
3、of pain experienced by a woman during labor and delivery can be influenced by many factors,including participation in childbirth preparation classes,parity,and use of oxytocin,ANALGESIA FOR LABOUR PAIN,Psychologic techniques -hypnosis -psychoprophylaxis -positive conditioning -patient education -acu
4、puncture -trenscutaeous electrical nerve stimulation,Systemic medication,Benzodiazepines -diazepan crosses the placenta rapidly,and maternal and fetal blood levels are equal within minutes of an IV dose if total maternal dosage exceeds 30mg, the drug and its active metabolite persist in pharmacologi
5、cal active concentrations for at least a week in the neonate,Systemic Medication,Diazepam -the adverse effects in neonate: .in large dose: hypotonia, lethargy, decreased feeding,and hypothermia .in small dose:reduced beat-to-beat variability. Midazolam -if it is used for induction,problem with genra
6、l body tone and body temperature of neonate seen.,Systemic Medication,Meperidine -peak analgesia effect occurs 40 to 50 minutes after Imand 5 to 10 minutes after IV -the duration is 3-4hours -can cause dose-dependent neonateal depression, as evidenced by prolonged time to sustained respiration,decre
7、ased Apgar scores,and abnomal results from neurobehavioral examination,Systemic Medication,Fentanyl -50ug to 100ug Imand 25ugIV -peak effect(IV)3-5min and duration 30-60min -A dose of 1ug/kg Ivto the mother within 15 min of cesarean delivery did not produce adverse effects -newborn drug levels were
8、always less than maternal levels,Morphine -peak analgesic effect occurs 1-2hoursIM and 20minutesIV -duration is 4-6hours -in equianalgesia doses,morphine produces more respiratory depression of the newborn than doses meperidine -morphine is reserved for early labor,Systemic medication,Butorphanol an
9、d nabuphine -synthetic agonist-antagonistnarcotic analgesics -do not cause respiratory depression in labor pt -cause maternal dizziness and somnolence and adverse neonatal neurobehavioral effects -rapidly cross placenta and increase FHR(cause high out put cardiac failure) -no advantage over other op
10、ioides,Systemic Medication,Ketamine -low dose Ivketamine (10-25mg, or 0.25mg/kg increments) can be used with inhaled agents to produce analgesia (which can be useful during operateive vaginal delivery or cesarean delivery),Systemic medication,Inhaled analgesia -proper administion of inhaled analgesi
11、a by mask in low concentrations to prevent loss of consciousness and protective aieway reflexes. -vomiting or silent regurgitation are possible aspiration risk -nitrous oxide in 50%with oxygen,reliable analgesia has not been demonstrated,Regional anesthesia,Most effective -provide pain relief, keep
12、patient awake and allow patient to participate in the labour and delivery process Unlikely to produce drug-induced depression in the fetus or mother Reduce levels of catecholamines in the mother ,which may beneficial to fetus,Regional anesthesia,Early placement of epidural catheter helps control blo
13、od pressure with good analgesia for labor pain in pre-eclampsia patient(after well hydration and before coagulopathy occurs)It may be the means to reduce cesarean section rate in China,Regional anesthesia,Patient preparation -IV -equipment for resuscitation and complication -O2,airways,laryngoscope,
14、endotracheal tubes,suctioning apparatus,thiopenal or diazepam,ephedrine and naloxone -preanesthetic evaluation, OB plan and understand fetal status -BP, ECG and FHR and 500ml IV fluid,Regional anesthesia,Contraindications -absolute .patient refusal, infectin at the site of needle placement, overt ma
15、ternal coagulopathy, and maternal hemodynamic instability -relative .preexisting neurologic disease, prior back surgery,isolated coagulation abnomalities, some cardiac disease,Regional anesthesia,Timing of administration -chestnut et.al. performed a study wherein patients were randomized to early (i
16、e,1st request0epidural or late (waiting until at least 5cm cervical dilation).No difference in cesarean rates was found between the two groups for either spontaneous or induced labors,and the cesarean rate was low (approximately 8%)in both,Regional anesthesia,Encourage early administration of epidur
17、al anesthesia in laboring women with preeclampsiaEpidural anesthesia did not increase the incidence of cesarean delivery or pulmonary edema among laboring women with severe hypertensive disease,Regional anesthesia,One shot spinal analgesia using a lipid soluble opioid is rapid and simple, but is ass
18、ociated with a limited duration of action,Regional anesthesia,Epidural analgesia provides excellent pain relief and the ability to extend the duration of the block to match the duration of labour ,but it is not “instant “in onset and may be associated with motor block,Regional anesthesia,The combina
19、tion of epidural and spinal anesthesia into one technique,termed “combined spinal-epidural provides the advantages of a spinal with the additional flexibility of renewal with an epidural catheter,Regional anesthesia,Intrathecal narcotic provides excellent pain relieve instantly without motor blockCS
20、E has special benefit if patients cervical dilation is about 8cm More than 60% of patients in my hospital receive CSE analgesia now,Regional anesthesia,Intrathecal opioids -sufentanil 2.5ug-10ug -fentanyl 10-25ugSide effects prurtus,nausea/vomiting,hypotension,urinary retention,uterine hyperstimulat
21、ion and fetal dradycardia,maternal respiratory depression,Epidural anesthesia,The block is placed once the patient is in established labor.Low doses of local anesthesics or opioids are often sufficient during the first part of labor to provide an effective T10-L1 segmental block.Increased local anes
22、thetics to cover S2-S4 for second sstages of labor,Epidural analgesia,Use dilute local anesthetics and opioid solutions(0,125%bupivacaine or ropivacaine with fentanyl or sufentanil)Make every dose a test dose -2-3ml initial bolus(look for intrathecal injection),Epidural analgesia,Value of epinephrin
23、e “test dose”(15ug produce increased heart rate of 20-30/min) in the parturient ,epinephrine produces an indistinct tachycardia,which can be confused with pain-induced heart rate changes -epinephrine produces a more readily detected tachycardia if patients are already painfree(afterantrathecal drug
24、injection),Epidural analgesia,Epidural opioids for labor -meperidine 100mg-last 2.5hours -fentanyl 100-200ug,onset 5-10min,last 1-2hours -sufentanil5-15ug last 1hr,40-50ug last 5hr.,Epidural analgesia,Bupivacaine-long duration,lower motor block than lidocaine-beware of cardiotoxicity and do not use
25、the concentrarion of 0.75%.lidocaine -most common used for cesarean delivery,Epidural analgesia,2-chloroprocaine -ester type,fast onset,brief duration -useful to rapidly extend a labor epidural block for operative vaginal(2-3%)or cesarean(3%)delivery -a disadvantage is it apprarent antagonism of sub
26、sequently injected epidural opioids and bupivacaine,Epidural analgesia,Ropivacaine newer amide local anesthetics similar in structure ,potency,and pharmacodynamics to bupivacaine cardiotoxicity that is intermediate between those of lidocaine and bupivacaie,Epidural analgesia,Continuous epidural infu
27、sion -0.04%bupivacaine plus fentanyl:almost all patients will require at lease one resuse bolus,some need more than seven -0,083%bupivacaine plus sufentanil:53%requre at least one rescue,18%need two or more -complication:intravascular or intrathecal infusion,Epidural analgesia,Patient controlled epi
28、dural analgesia minimize drug dosage.flexibility and benefits of self administration reduced demand on professional time controversy still exists regarding the use of a continuous basal infusion in addition to patient controlled boluses which would provide for a more even block and larger doses,Epid
29、ural analgesia,Complications -hypotension -convulsion -cardiac arrest deliver the fetus,external cardiac massage defibrillation epinephrine bretylium -total spinal airway,trendelenburg,fluid,pressure support,Epidural analgesia,Complications nerve injury rare epidural hematoma infection, meningitis h
30、eadache,Regional anesthesia,CSE rapid onset reliability patient can walk if only intrathecal opiate given (in Ob patient) epinephrine test dose for epidural catheter placement is more reliable after intrathecal opiate is given because the patient is pain free,Complication of cesarean section,Uterine
31、 laceration,uterine atony and increased risk of placenta accretaBladder,ureteral injury and G1 tract injury Infection of wound and uterine post-opRupture of uterrrrrrusAnesthsia related Death rate;5.6-6.1/100,00,Possible strategies to reduce the rate of cesarean section,Equalize the reimbursement fo
32、r vaginal and cesarean deliveriesPublish physician-specfic cesarean ratesPublish hospital-specific cesarean rates Address physician malpractice concern though legislation,Application of CSE in the operating room,Abdominal surgeries such as colectomy,bilateral recurrent inquinal heria repair and abdo
33、minal aortic aneurysm repairOrthopedic surgeries such as total knee replacement and total hip replacement,Application of CSE in the operating room,Provides reliable spinal anesthesia aand epidural anesthesia availability if surgery is longer than expectedProvides epidural analgesia for post-op pain control,