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1、1 1.Takentogether,ourdataprovidenewmechanisticinsightsintopossibleendogenoussignaling metastatic signaling pathways involved in maintaining proliferation andmigrationofbreastcancercells.2.Wesoughttodeterminewhetherseliciclib(CYC202,Rroscovitine)couldincreasetheantitumoreffectsofdoxorubicin,withnoinc
2、reaseintoxicity,inanMCF7breastcancerxenograftmodel.3.MIB1(ki67)immunohistochemistry demonstrated reduced proliferation withtreatment.4.Survivinembodiestheseproperties,and5.Moreover,in preclinical bladder tumor models,inhibition of Survivin expressionand/orfunctionhasbeenshowntoimpedetumorcellprolife
3、ration,andmarkedlyinducespontaneousorchemotherapyinducedapoptosis6.Theefficacyofmainstaycancertherapies,cytotoxicsandradiation,hasreachedaplateau in the treatment of many cancers,and there is an urgent sense thatimprovementsmustnowcomefromfreshapproaches.7.Medianagewas62yearswitharangeof4074years.8.
4、splicevariantsmightfunctionineffectasdominantnegativessothattheirexpressionmightconcurrentwithsurvivin.9.ThereisahypothesisthatXXX10.TheabsenceofinvivodataonthispointhasnowbeenremediedwithapaperinthisissueoftheJCIbyAltieriandcolleagues.11.Thus,thisraisesaninterestingquestionwhether.12.raisingtheposs
5、ibilitythatmost,ifnotall,tumorsexpress.13.Thelevelsofp21andp27increasedaftertreatmentwithdoxorubicinorseliciclibaloneorincombination,comparedtountreatedcontrols.14.Incontrast,itisabundantlyexpressedinawidevarietyofmalignanttissues.15.Onthecontrary,.2 16.Bycontrast,agoodtitlewillattracttherelevantres
6、earchersandincreasethenumberofcitationsyoureceive17.WehavefoundthatthehumanbreastcancercellsMCF7/AdroverexpressnotonlyPgpbutalsoXIAPandSurvivin,andshowedhighresistancetochemotherapeuticdrugsdoxorubicin,docetaxelandvincristine,incontrasttotheirparentalcellsKBandMCF7.18.Survivinisaberrantlyexpressedin
7、variouskindsofcancercellsbutisundetectableinnormaldifferentiatedadulttissues,withtheexceptionoftestis,thymus,andplacenta.19.TheattributablemortalityofCVCrelatedbloodstreaminfectionsrangesfrom0%to11.5%,20.Giventheselowrates,itisnotclearwhethernewtechnicaldevicesconferfurtheradvantages21.Patientswitha
8、historyofallergytochlorhexidineortotransparentdressingswereexcluded.22.Recurrenceisdifficulttotreatandincurableinmostpatients23.Shealsorunstheriskofinfectionbecauseshehasnospleenandwillhavetotakepenicillinforafewmonths.24.usingthesesitescarriedanincreasedriskofnoninfectiouscomplications25.Patientswi
9、thgastroparesisareatincreasedriskforaspirationpneumonitis26.Someresearchsuggeststhatfrequentconsumptionoffruitandvegetablecancuttheriskoflungcancereveninsmoke.27.sincelowerLDLwaslinkedtosmallerriskofvascularevents.28.However,radiotherapyisanexpensivetreatmentandislinkedtotheincreasedriskofotherlasti
10、ngcomplications,suchasimpairedbowelfunction,incontinence,andsexual dysfunction.For that reason,radiotherapy should be targeted to patientsshowing a high risk of local recurrence,such as those with involvement of thecircumferentialresectionmargin.3 29.butreachedthesimilarconclusionthatHDACwasinvolved
11、intherepressingeffectsofp53onsurvivinexpression30.Thisstudyevaluatedthechoiceinusingchemoradiotherapyinpatientswhohadinvolvement of the circumferential resection margin,with one week sessions ofradiotherapypriortosurgery.31.Totalmesorectalexcisionisoneofthelatestadvancesinsurgicaltechniquesthathavee
12、nhancedpatientoutcomes32.Thatpreoperativeradiationcanmitigatebutnoteliminatetheadverseeffectsofimperfect surgery.The best outcomes occurred when preoperativeradiation wasfollowedbyoptimumsurgeryThenextchallengeistounderstandwhichpatientneedswhattherapytomaximisehisorherchanceforcure.33.Whilehersutur
13、esheal,Heatherhasastoma34.exercisehelpsyourecoverfromaheartattackbutonlyifyoukeepitup.35.Theauthorswrotethatwealreadyknowthatexercisebenefitspatientswithcoronaryarterydisease,butthereislittleevidenceonwhichtypesofexercisehavethemostimpact.36.The researchers measured the participants endothelial func
14、tion(flowmediateddilation)beforeandafter4weeksofdifferenttypesofexercisetrainingandthenafter1monthofnotraining.37.Vonasaiditwasimportanttokeepexercisinginthelongerterm.38.Thefollowuplasted（notwas）14122months39.All 23 patients met the criteria for establishing the diagnosis of the nutcrackersyndrome4
15、0.Noperioperativecomplicationswereencountered41.Pleasefeelfreetocontactmeifyouhaveanyquestions.42.Attentionisalsoshiftingfromtheosteoclastasatargetfornewtherapiestotheosteoblastandtheosteocyte,withitscomplexnetworkwithinthedepthsofbone.4 43.its application in oncology would become greatly limited be
16、cause its efficacy isachievedattheexpenseoffataltoxicity.44.Bronchiectasisdiffersfromchronicbronchitisinthattheformerismoreofalocalizeddisease.支气管扩张与慢性支气管炎的区别在于前者更是一种局限性疾患。45.Successful experiments in immunology have proved a great hope in its furtherapplicationasapowerfultherapeuticanddiagnosticwea
17、pon.46.Themodernworldisexperiencingrapiddevelopmentofscienceandtechnology.47.Theprolongeduseofsystemicantibioticsinacnemayresultinadistinctivesyndromethatisexceptionallydifficulttodealwith.48.Here,weoutlinestrategiesforidentificationofpatientsatriskandforpreventionandpossibletreatmentofthisimportant
18、entityofchronicpain.49.Infact,inpatientswithinsulinresistance(ie,metabolicsyndrome),decreasedinsulininduceduricacidexcretionmayaccountfortheobserveduricacidderangements.50.Althoughmodernmedicinehasmadetremendousadvances,cancerisstilloneofthemostdangerousdiseases51.Thisrevolutionaryforceinmedicine,es
19、peciallyinthefieldofantibacterialagents,isnowadvancinginitsfullswing;moreandgreaterbreakthroughsarestillexpected.(用于展望)在医药方面，特别是在抗菌药物领域中的这股新力量，正在全力进展；更多的和更大的突破仍有望出现。52.Wethoughtitnecessarytoperformanexploratorythoracotomy.我们认为有必要做剖胸探查。如果不省略 it，则翻译为：我们认为这是必要的去做剖胸探查。这也是非常拗口的翻译。53.Theytrainedthreetofou
20、rtimesperweekoutofconcerntheywouldovertrainorbecomestale.54.Following the use of antibacterial agents there is a profound alternation anddisturbanceofthenormalbacterialequilibrium.随着抗菌药物的使用，正常的细菌平衡状态发生了深刻的变化和紊乱现象。5 55.Diseasesassociatedwithatherosclerosisareanincreasingprobleminmostpartsoftheworldan
21、d,aswithmanyotherproblemsoftoday,arebecomingmoreandmoreurgentfortheyoungergeneration.56.Ifheredityiscomplex,equallysoisenvironment.如果说遗传因素是复杂的，那么环境因素亦是如此57.Antibioticshavebeenusedtodealwithalmostallknownbacteria.Withoutthem,wecouldnothavesavedsomanylives.58.Hewillperformanoperationonherforadiseasedl
22、ung.59.Thetemperaturewillfalltonormalwithin48hours.60.Heavysmokinggreatlyincreasedtheprobabilityofhavinglungcancer.61.cure；heal；treat；cure 表示治疗、医治的意思，在现代英语中，多指药对疾病有效，治愈疾病，使人恢复健康。Thephysiciancuredhimofthedisease.医生治好了他的病。heal 它的意思是医治、愈合，多指治愈伤口或创伤，使之复原。Thesurgeonhealedhiswound.外科医生治好了他的伤口。Treat 医治、治疗(
23、病人、疾病等)，只指予以医治。Howwouldyoutreatacaseofrheumatism?你怎样治疗风湿病?62.Earlyandaggressivetreatmentofhemolyticstreptococcalinfectionswithpenicillinreduces the incidence of rheumatic fever following such infections;but afterrheumaticfeverhasbeentriggered,treatmentwithantimicrobialagentsisineffective.63.Thereaso
24、nthatonetissueororgan,suchasstomach,candigestfood,andanothertissueororgan,suchasamuscle,canmovealimb,isthatthecellsofwhicheachtissueororganismadearedifferent.64.Insuchcases，heartmurmurisoftenpresent.这类病例常常出现心脏杂音。65.Insuchacasethepatientshouldbeencouragedtobeupandabout.66.Onsomeoccasionsitisimportant
25、to67.Mostattentionhasbeendirectedatthestudyofthespreadofthesetumorsthroughthelymphaticsystem,andatthatoftheinfluencethatlymphaticmetastasishason6 theprognosisaftersurgery.68.Oneofthefundamentalassumptionsinthestudyofshockhasbeenthat 研究休克的基本设想之一一直是69.Itisusuallypostulatedthat 通常认为70.Largescalecollect
26、ionandprocessingunderway71.Adoubleblindtrialwascarriedoutamong470patients,ofwhomabout70%weremaleswithpostoperativepain.72.Significantfever,leucocytosis,andaboveall,rigorsshouldarousesuspicionandsoshouldthepresenceofsepsis.73.Nevergivemorphinetounconsciouspatients,patientswhohaveheadinjuries,thosewit
27、hrespiratorydepression,orthosewithoutpain.74.Tetracyclinehasnodemonstrableeffectsonthecentralnervoussystem,neitherhaschloromycetin.四环素对中枢神经系统没有明显作用，氯霉素对中枢神经系统也没有明显作用。75.Thereisnothingillogicalintheideathatvirusesorviruslikeagentsmaybethebasiccauseofcancers,althoughrequiringthecooperation,asweshallse
28、e,ofnutritional,hormonal,geneticandothermetabolicfactors.76.Thetherapymustnotbeinterrupteduntilasatisfactoryclinicalandhematologicalremissionoccurs.血象好转77.Protein/carbohydrate interactions through specific protein families termed lectincontrolessentialbiologicalprocesses。Galectins,afamilyofanimallec
29、tinsdefinedbysharedaminoacidsequencewithaffinityforbgalactosides,appeartobefunctionallypolyvalentinawiderangeofbiologicalactivity.Galectin1andgalectin2contributetothesuppressionof78.bcl2andsurvivincontributeindependentlytoembryonicandfetaldevelopment.contribute 的用法79.However,thebiologicalfunctionsan
30、dcontributionstocancerprogressionofsurvivin7 splicevariantsarecontroversiallydiscussed.80.Lowrecurrencerateswererelatedtoanegativecircumferentialresectionmarginandasuperiorplaneofsurgery.81.Survivin positivity was independently related to inferior survival irrespective oftreatmentwithorwithoutradiot
31、herapy82.SurvivinisstronglyexpressedinHNSCC,anditsproposeddualroleasanapoptosisinhibitorandamitoticeffectorpositionedsurvivininthefrontlineofcancerresearch.83.Headandnecksquamouscellcarcinomas(HNSCC)ischaracterizedbylocaltumoraggressiveness,highrateofearlyrecurrences,metastasisanddevelopmentofsecond
32、primarycarcinomas.Overthelastdecades84.Locoregional relapse after therapy is a major cause of death despite moderntherapeutic strategies like radio and chemotherapy in addition to sophisticatedsurgicalmanagementofthetumor85.Consequently,overallsurvivinexpression,itsdistinctintracellularlocalizationa
33、nditssignificanceasaprognosticmarkerwereanalyzedinmanyHNSCCpatientstudies,albeitwithopposingconclusions86.Thisisquitelong,containssomegrammaticalproblemsandsaysnothingabouttheantitumoreffects.However,thisisstillfairlylong.87.Yourpapersabstractiscriticalbecausemanyresearcherswillreadthatpartonly,rath
34、erthanreadingtheentirepaper.88.whereitisfreetointeractwithApaf1andcaspase9toformanactive“apoptosome”complexinducingacascadeofcaspaseactivityandensuingcelldeath89.Moreover,weandothershavefoundthatoverexpressionofErbB2confersonbreastcancercellsanincreasedresistancetoTaxol90.Notwithstandingthiseyecatch
35、ingtitle,themajorfocusoftheeditorialhadtodowithDr.Bieseckers thoughtful comments on the gathering,storing,retrieval,andpublicationofclinicaldatainthefieldofmedicalgenetics.8 91.Someconventionalantitumortherapies,includingDNAdamagingandantimicrotubule agents,exert their function by activating the int
36、rinsic apoptosispathway92.hTERTactivityisinducedbycMycandstrategiesdesignedtoinhibitcMycexpressionincancercellsmayhaveconsiderabletherapeuticvalue.93.Inaddition,cMychasalsobeenimplicatedintheregulationoftelomerasethroughitsabilitytoinducethetranscriptionalactivationofhTERT94.Inthepresentstudy,wesele
37、ctivelydownregulatedcMycexpressioninhumancoloncancer Colo 320 cells with siRNA delivered via a plasmidbased polymerase IIIpromotersystem.ThisapproachallowedustoexploreapossibleroleforcMycinregulatingtelomeraseactivity.95.Tamoxifen is a drug of choice for endocrineresponsive breast tumor patients.How
38、ever,tamoxifenresistancehasbecomeamajorconcernforthetreatmentofbreastcancer.Combinationaltherapiesoftamoxifenanddifferentdrugsarebeingfrequentlystudied.96.Combinational（combinatorial）treatmentofgapjunctionalactivatorandtamoxifeninbreastcancercells.97.Inthisstudy,wetestedtheefficacyofsubstitutedquino
39、lines(codename=PQ1;agapjunctionalactivator)incombinationwithtamoxifeninT47Dcells.98.Thissuggeststhatanincreaseingapjunctionactivitycanpotentiatetheeffectoftamoxifen.99.genestocancercellsisanewandpromisingmodalityfortreatmentofcancer.100.The monoclonal antibody trastuzumab and the EGFR/HER2 tyrosine
40、kinaseinhibitorlapatinibimprovetheclinicaloutcomeofpatientswithHER2overexpressingbreastcancer.However,themajorityofmetastaticcancerswilleventuallyprogresssuggestingtheneedforothertherapies.101.ThecombinationofAdHER2kipluslapatinibalsoshowedsuperiorantitumor9 efficacyinvivo.102.NFDinduced Sphase arre
41、st was associated with a marked decrease in theproteinexpressionofcyclinA103.NFDinduced apoptosis was characterized by increase of subG1 population,phosphatidylserine(PS)externalization,andactivationofcaspases.104.Incaseyouencounteranydifficultieswhilesubmittingyourmanuscriptonline,pleasegetintouchw
42、iththeresponsibleEditorialAssistantbyclickingon“CONTACTUS”fromthetoolbar.105.Weappreciateanyeffortsthatyoumaketoensurethatthelanguageiscorrectedbeforesubmission.ThiswillgreatlyimprovethelegibilityofyourpaperifEnglishisnotyourfirstlanguage.Inthisregard 有鉴于此106.Inordertofurtherexaminethepotentialmecha
43、nismsunderlyingtheseprocesses,significantresearcheffortisfocusingonDTCsinthebonemarrowasasurrogateforminimalresidualdisease.107.Inadditiontoitswelldocumentedantioxidantproperties,thereisincreasingevidencethat resveratrolexhibitsprooxidantactivityundercertainexperimentalconditions,causing oxidative D
44、NA damage that may lead to cell cycle arrest orapoptosis.108.Similarly,an integrated strategy and pharmacogenomics approach is nowessentialtofightagainstthismalady.109.AstrongracialpredilectionisnotedinMBC110.Thisisinstarkcontrasttothehighincidenceofmalebreastcancer111.Thelowincidenceofmalebreastcancerhashinderedinvestigatorsattemptstodeveloprandomizedprospectivetrials,sothediseaseispoorlyunderstood.112.Anexploratorystudyofsunitinibpluspaclitaxelasfirstlinetreatmentforpatientswithadvancedbreastcancer.