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1、肠易激综合征的新概念Newest concepts in irritable bowel syndromeIBS,张虎华西医院消化科,旧概念： 过敏性结肠炎 易激结肠 或黏液性结肠炎,新概念：一种以腹痛或腹部不适伴排便习惯改变为特征的功能性肠病 a group of functional bowel disorders in which discomfort or pain is associated with defecation or a change in bowel habit , and with features of disordered defecation.,该病缺乏可解释症
2、状的形态学改变和生化异常,Psychologic disturbance relates to patients who see physicians Psychosocial factors influence health care seeking,IBS Non-patients,normal,IBS patients,Psychologicdisturbance,IBS - Psychosocial,流行病学研究,西方国家 患病率 5-24% 美国 人群 10-20% 就诊率 30 $80亿 国内 北京 潘国宗 7.26 广州 陈旻湖 5.6 就诊率 22.4,What causes
3、IBS ?,Development of IBS pathophysiology inflammation 5-HT mediated hypersensitivity and gut motility Brain-gut interaction Visceral hypersensitivityAbnormal motor function1950 1960 1970 1980 1990 2000,Abnormal network regulationOf nerve-immune-endocrine,IBS molecular biology,.,IBS发病机制的认识,临床症状 腹痛、不适
4、大便异常，流行病学等第一阶段,IBS发病机制的认识,临床症状 运动异常 感觉异常 社会心理致病腹痛、不适 压力、电活动 大便异常， 敏感性、 5-HT流行病学等 炎症、脑肠交流第一阶段 第二阶段,Visceral Hypersensitivity hyperalgesia allodynia,EndogenousModulation.cortex.Brainstem,End organ sensitivity.silentnociceptors,SpinalHyperexcitability.Nitric oxideActivation,Long-termHyperalgesia.tonic
5、cortical regulation.Neuroplasticity,IBS发病机制的认识,临床症状 运动异常 感觉异常 社会心理致病腹痛、不适 压力、电活动 大便异常， 敏感性、 5-HT流行病学等 炎症、脑肠交流第一阶段 第二阶段,Serotonin(5-HT) in the human gut,5-HT1 5-HT3 5-HT4 Gastric accommodation Transit Colonic tone Sensation ? Secretion ,IBS发病机制的认识,临床症状 运动异常 感觉异常 社会心理致病腹痛、不适 压力、电活动 大便异常， 敏感性、 5-HT流行病学
6、等 炎症、脑肠交流第一阶段 第二阶段,Psychologic distress,Younger age,Duration of abdominal pain,Duration of diarrhea,Females,Factors PredictingGI Symptoms,IBS - Post Infectious,IBS发病机制的认识,临床症状 运动异常 感觉异常 社会心理致病腹痛、不适 压力、电活动 大便异常， 敏感性、 5-HT流行病学等 炎症、脑肠交流第一阶段 第二阶段,Mechanosensitive afferent,Sensitized spinal circuits,Dors
7、al root ganglion,Repeated stimulation,Descending Visceral Pain Pathway,Thalamus,PAG,Locus coeruleus,Amygdala,Colon,Serotonergic,Noradrenergic,Caudal raphe nucleus,Opioidergic,Rostral ventral medulla,MotilitySecretionBlood FlowInflammation,SightSoundSmellSomatosensory,CognitionAffect,Viscerosensory,I
8、nput,Integration,Effect,IBS发病机制的认识,临床症状 运动异常 分子生物学阶段 感觉异常 网络调控 社会心理致病腹痛、不适 压力、电活动 大便异常， 炎症、敏感性流行病学等 5-HT、脑肠交流第一阶段 第二阶段 第三阶段,一氧化氮5HT及受体多巴胺及受体胃肠道激素及受体细胞因子及受体细胞信号转导蛋白离子及离子通道, ,Extracellular network regulation,Nerve cells,Immune cells,Endocrine cells,Cytokine, receptor, peptide, 5-HT,How to develop in a
9、 person?,Predisposing factors,Psycho-Physiologicaltriggers,Concurrentmodifiers,Brain-gutdysregulation,Earlylife,Genetic vulnerability,Enviromnent eg illnessBehavior reinforcement,abuse,Predisposing factors,Psycho-Physiologicaltriggers,Concurrentmodifiers,Brain-gutdysregulation,Earlylife,Genetic Envi
10、ronment,Chronic threat & prolonged effortful coping,EntericInfection/Inflammation/toxins,Predisposing factors,Psycho-Physiologicaltriggers,Concurrentmodifiers,Brain-gutdysregulation,Earlylife,Genetic Environment,Chronic threat & prolonged effortful coping,EntericInfection/Inflammation/toxins,Stress-
11、responseneuromodulation,Post-infectiveneuromodulation,Personality, emotionalSupport, age, gender,Sleep dysfunction,Life event stress,Food allergens,Altered bowel flora,Predisposing factors,Psycho-Physiologicaltriggers,Concurrentmodifiers,Brain-gutdysregulation,Early life,Enteric infectionInflammatio
12、n,trauma,Stress-responseneuromodulation,Post-infectiveneuromodulation,Personality, emotionalSupport, age, gender,Sleep dysfunction,Life event stress,Food allergens,Altered bowel flora,Prolonged threat&effortful coping,CNS,ENS,CorticalArousal(anxiety),Visceralhypersensitivity,GI symptoms,EI symptoms,
13、IBS,Dysmotility,AlteredEpithelialpermeability,How to diagnose ？,诊断,以症状为基础,诊断标准,Manning标准 1978年Rome I 1992年 Rome II 1999年Rome III 2006年 ?2003年三月 广州首届全国IBS会议 决定采用国际认同的Rome II 诊断标准,Rome I Criteria Rome II Criteria, at least 12 weeks, which need not be consecutive, in the past 12 months, of abdominal di
14、scomfort or pain that has two of three features -relieved by defecation; and/or -onset associated with a change in frequency of stool; and/or -onset associated with a change in form(appearance) of stool, At least 3 months continuous / recurrent symptoms of the following -Abdominal pain or discomfort
15、 that is -associated with a change in frequency of stool and/or -associated with a change in consistency of stool; and Two or more of the following at least 25% of the time altered stool frequency (3/day or 40岁,诊断流程,问诊查体,有 无,发热、消瘦、便血、腹部包块,彻底检查,近期排便习惯改变、肿瘤家族史、40岁,肠镜或钡灌肠,大便常规OB,是,否,What is the best ma
16、nagement approach?,治疗,个体化、综合治疗,治疗原则,A comprehensive multicomponent approachTreatment program is based on dominant symptom and their severity, and on psychosocial factors , and etiological factors,Drugs for dominant in IBS,Abdominal pain,AntispasmodicsTricyclicAntidepressantsSSRI,Diarrhea,Constipatio
17、n,FiberOsmotic laxativesTegaserodPEG solution,LoperamideCholestyramineDiphenoxylate,治疗原则,A comprehensive multicomponent approachTreatment program is based on dominant symptom and their severity, and on psychosocial factors , and etiological factors,Mild Lifestyle and dietary modification,Severe Real
18、istic goalsAntidepressants Referral for pain management,Moderate Gut acting agents Psychologic (motility/sensation) treatments,All Therapeutic relationship/continuity of care education/reassurance,治疗原则,A comprehensive multicomponent approachTreatment program is based on dominant symptom and their severity, and on psychosocial factors , and etiological factors,心理治疗,What can we do?How to do?,心理治疗,第一层次：一般性心理治疗或支持性心理治疗（supportive psychotherapy）,第二层次：心理治疗干预(psychotherapeutic intervention),DefinitionPathogenesisDiagnosisTreatment,谢谢,