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1、 VIII. Preparation of Microcapsules采用复凝聚法制备磺胺二甲嘧啶微囊和单凝聚法制备液状石蜡微囊，并在显微镜下观察成囊状态。Purpose1. To master the basic principle and methods of simple coacervation and complex coacervation.2. To understand the factors that influence microcapsules forming.Equipments and Materials1. EquipmentsElectromagnetic ble
2、nder, cleansing bath tub, beaker (500, 250 and 50ml), pestle, microscope, scales etc.2. Materials Gelatin “A”, acacia, sulfamerazine, chrismaline, 37% methyl aldehyde solution, 10% acetic acid solution, 60% sodium sulfate solution, etc.ProceduresSulfamerazine microcapsules(1) FormulationSulfamerazin
3、e ( SM2) 1.2gGelatin 1gAcacia 1g10% Acetic acid solution proper quantity37% Methyl aldehyde solution 1.6ml(2) Preparation1) Preparing colloid solution2) Suspending3) Coagulating and solidifying4) Granulation and DryingChrismaline microcapsules(1) FormulationChrismaline 2gGelatin 2g10% Acetic acid so
4、lution proper quantity60% Sodium sulfate solution proper quantity37% Methyl aldehyde solution 3mlDistilled water proper quantity(2) Preparation1) Preparation of gelatin solution2) Preparation of chrismaline emulsion3) Preparation of microcapsulesQuestions1. To draw the shape of microcapsules prepared in simple and complex coacervation separately and explain mechanism of microencapsulating.2. Try to analyze the factors influencing microcapsules diameter of microcapsules.3. Try to analyze the factor influencing drug release from microcapsules.