《阿尔茨海默症英语介绍.pptx》由会员分享，可在线阅读，更多相关《阿尔茨海默症英语介绍.pptx（21页珍藏版）》请在taowenge.com淘文阁网|工程机械CAD图纸|机械工程制图|CAD装配图下载|SolidWorks_CaTia_CAD_UG_PROE_设计图分享下载上搜索。
1、Ronald Wilson ReaganRonald Wilson Reagan罗纳德罗纳德威尔逊威尔逊里根里根第第40任（第任（第49-50届）美国总统届）美国总统 president president“I know Im on my way to the twilight.I know theres always a“I know Im on my way to the twilight.I know theres always a bright dawn ahead of the United states.Thank you,my friends.bright dawn ahead
2、of the United states.Thank you,my friends.May God bless you forever.”May God bless you forever.”第1页/共21页01030204Catalog第2页/共21页brief introduction1第3页/共21页What?Alzheimers disease(AD)is a progressive neurodegenerative disorder.临床症状Clinical symptom记忆障碍dysmnesia失语aphasia失认agnosia执行功能障碍executive dysfunct
3、ion痴呆dementiaThe disease usually begins after age 60,and risk goes up with age.第4页/共21页Two typesAlzheimers disease(AD)65 years oldsenile dementia(SDAT)65 years old第5页/共21页NameIn1906,ADisnamedbyDr.AloisAlzheimer,aGermandoctor.Dr.Alzheimernoticedchangesinthebraintissueofawomanwhohaddiedofanunusualment
4、alillness.Hefoundabnormalclumps.ScientistsalsohavefoundotherbrainchangesinpeoplewithAD.Nervecellsdieinareasofthebrainthatarevitaltomemoryandothermentalabilities.第6页/共21页Clinical manifestation2第7页/共21页Clinical manifestation期期期death1-31-3 yearsyears2-102-10 yearsyears8-12 years8-12 yearsMild dementiaM
5、ild dementiaModerate dementiaModerate dementiaSevere dementiaSevere dementiaMore women than men More women than men 7:54:67:54:6Disease for up to 10-20 yearsDisease for up to 10-20 years第8页/共21页Degradation of memory and cognitionWilliam Utermohlen的自画像的自画像第9页/共21页Degradation of memory and cognitionWi
6、lliam Utermohlen is an American artist,in 1995 he was diagnosed with Alzheimers disease.Since then,he has decided to take advantage of the limited time available to retain memory and better understand himself through self portraits.William insisted the 5 New Year paintings self portrait,until comple
7、tely forgotten how to draw.From the use of skilled drawing,dark portrayal of vivid features,to the same color,shape deformation,self portrait became more and more abstract(pictured above).第10页/共21页Degradation of memory and cognition the effects of Alzheimers disease on the right parietal lobe of the
8、 brain are particularly severe,which directly affects the ability of the brain to visualize and develop the ability to draw pictures of the brain.said Dr.Bruce Miller,a neurologist.His work became more abstract,may be the parietal function damaged,causing blindness.What kind of changes have occurred
9、 in the brains of patients with dementia,which is not yet fully understood by the world s academia.第11页/共21页PathogenyTreatment3第12页/共21页PathogenesishypothesisofAD第13页/共21页PathogenyAbnormal amyloid beta cell deposition in neuronsAbnormal phosphorylation of tau proteinvs第14页/共21页Beta amyloid(blue curv
10、e)and Tau protein(orange Beta amyloid(blue curve)and Tau protein(orange curve)curve)Research papers published Research papers published in recent 30 yearsin recent 30 years第15页/共21页Treatmentincrease the concentration of acetylcholine(Ach)in the brainpromoting survival of cholinergic neurons in the b
11、rain or improving their nerve conduction functionreducing the production or promoting degradation of beta amyloid第16页/共21页Other4第17页/共21页StillAliceFilmThefilmtellsthestoryofAliceHowlandinseriouslyADbutstillstrongandbrave.Thefilmwontheeighty-seventhOscaraward第18页/共21页TheNotebookMemoriesofTomorrow第19页/共21页Thankyou第20页/共21页感谢您的观看！第21页/共21页