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1、ARTIFICIAL SKINMaierdanjiangWufuer买尔旦江旦江吾甫吾甫尔DepartmentofPlasticandReconstructiveSurgery,InstituteofHuman-EnvironmentInterfaceBiology,CollegeofMedicine,SeoulNatlUniversity,Seoul,RepublicofKoreaBiomedicalResearchInstitute,SeoulNatlUniv.Hospital,Seoul,RepublicofKoreaApligrafCountryObjectiveEpidermisDe
2、rmis/Matrixgraft?FDA&IndicationstoragUSA,Organogenesis,Inc.Epidermal/DermalreplacementKeratinocytesfromhumanneonatalforeskintissueBovinecollagenIgelwithallogeneicNOFDA1998,approvedforuseinthetreatmentofdiabeticfootulcersandvenouslegulcers.37incubator,viablefor2-3daysdifferentiationApplicationAdvanta
3、gesDisadvantagesPriceMoreinfoReference10days1.Preparewound2.Applyapligraf3.DresswoundWounddressingwithtwodifferentcelltypes,3timesfasterhealingindifficultwounds/Mostexpensive,shortshelf-life$1,100./42cm2abilaminarstructureformedbytypeIbovinecollagengelpopulatedbyliveneonatalfibroblastscoatedwithalay
4、erofepithelialcellsWilkinsLM,WatsonSR,ProskySJ,etal.Developmentofabilayeredlivingskinconstructforclinicalapplications.BiotechnolBioeng.1994;43747-756.2.ParenteauNL,NolteCM,BilboP,etal.Epidermisgeneratedinvitro:practicalconsiderationsandapplications.JCellBiochem.1991;45:245-251OrCelCountryObjectiveEp
5、idermisDermis/MatrixSTG?FDA&IndicationstoragUSA,ForticellBioscienceInc.,NYEpidermal/dermalreplacementkeratinocytesderivedfromneonatalforeskin,Bovinecollagenspongewithallogeneicfibroblastsandkeratinocytes）no2001,FDAapprove,partial-thicknesswounds37incubatordifferentiationApplicationAdvantagesDisadvantagesPriceMoreinfoReference37incubator1.Preparewound2.Applyorcel3.Dresswoundwhereitprovidesafavourablematrixforhostcellmigration.expensive$1,200/44cm2OrCelisabilayerdressingresemblingnormalskinandwasdevelopedasatissue-engineeredbiologicaldressing.https:/www.i-