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1、You might resemble or act more like your mother, but a novel research study from UNC School of Medicine researchers reveals that mammals are genetically3 more like their dads. Specifically, the research shows that although we inherit equal amounts of genetic2 mutations from our parents - the mutatio
2、ns that make us who we are and not some other person - we actually use more of the DNA5 that we inherit from our dads. The research, published in the journal Nature Genetics, has wide implications for the study of human disease, especially when using mammalian research models. For instance, in many
3、mouse models created for the study of gene1 expression related to disease, researchers typically dont take into account whether specific genetic expression originates from mothers or fathers. But the UNC research shows that inheriting a mutation4 has different consequences in mammals, depending on w
4、hether the genetic variant6 is inherited from the mother or father. This is an exceptional new research finding that opens the door to an entirely7 new area of exploration in human genetics, said Fernando Pardo-Manuel de Villena, PhD, professor of genetics and senior author of the paper. Weve known
5、that there are 95 genes8 that are subject to this parent-of-origin effect. Theyre called imprinted9 genes, and they can play roles in diseases, depending on whether the genetic mutation came from the father or the mother. Now weve found that in addition to them, there are thousands of other genes th
6、at have a novel parent-of-origin effect. These genetic mutations that are handed down from parents show up in many common but complex diseases that involve many genes, such as type-2 diabetes10, heart disease, schizophrenia, obesity11, and cancers. Studying them in genetically diverse mouse models t
7、hat take parent-of-origin into account will give scientists more precise insights into the underlying12 causes of disease and the creation of therapeutics or other interventions13. The key to this research is the Collaborative Cross - the most genetically diverse mouse population in the world, which
8、 is generated, housed, and distributed from UNC. Traditional lab mice are much more limited in their genetic diversity, and so they have limited use in studies that try to home in on important aspects of diseases in humans. The Collaborative Cross bred together various wild type mice to create wide
9、diversity in the mouse genome. Pardo-Manuel de Villena said that this diversity is comparable to the variation found in the human genome. This helps scientists study diseases that involve various levels of genetic expression across many different genes.单词解析表：1 gene n.遗传因子，基因参考例句：A single gene may ha
10、ve many effects.单一基因可能具有很多种效应。The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。2 genetic adj.遗传的，遗传学的参考例句：Its very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。3 ge
11、netically adv.遗传上参考例句：All the bees in the colony are genetically related. 同一群体的蜜蜂都有亲缘关系。Genetically modified foods have already arrived on American dinner tables. 经基因改造加工过的食物已端上了美国人的餐桌。 来自英汉非文学 - 生命科学 - 基因与食物4 mutation n.变化，变异，转变参考例句：People who have this mutation need less sleep than others.有这种突变的人需
12、要的睡眠比其他人少。So far the discussion has centered entirely around mutation in the strict sense.到目前为止，严格来讲，讨论完全集中于围绕突变问题上。5 DNA (缩)deoxyribonucleic acid 脱氧核糖核酸参考例句：DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。6 variant adj.不同的，变异的；n.
13、变体，异体参考例句：We give professional suggestions according to variant tanning stages for each customer.我们针对每位顾客不同的日晒阶段，提供强度适合的晒黑建议。In a variant of this approach,the tests are data- driven.这个方法的一个变种，是数据驱动的测试。7 entirely ad.全部地，完整地；完全地，彻底地参考例句：The fire was entirely caused by their neglect of duty. 那场火灾完全是由于他
14、们失职而引起的。His life was entirely given up to the educational work. 他的一生统统献给了教育工作。8 genes n.基因( gene的名词复数 )参考例句：You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因，所以能够活得很长。 来自简明英汉词典Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学
15、 - 生命科学 - 生物技术的世纪9 imprinted v.盖印（imprint的过去式与过去分词形式）参考例句：The terrible scenes were indelibly imprinted on his mind. 那些恐怖场面深深地铭刻在他的心中。The scene was imprinted on my mind. 那个场面铭刻在我的心中。 来自简明英汉词典10 diabetes n.糖尿病参考例句：In case of diabetes, physicians advise against the use of sugar.对于糖尿病患者，医生告诫他们不要吃糖。Diabe
16、tes is caused by a fault in the insulin production of the body.糖尿病是由体內胰岛素分泌失调引起的。11 obesity n.肥胖，肥大参考例句：One effect of overeating may be obesity.吃得过多能导致肥胖。Sugar and fat can more easily lead to obesity than some other foods.糖和脂肪比其他食物更容易导致肥胖。12 underlying adj.在下面的，含蓄的，潜在的参考例句：The underlying theme of th
17、e novel is very serious.小说隐含的主题是十分严肃的。This word has its underlying meaning.这个单词有它潜在的含义。13 interventions n.介入，干涉，干预( intervention的名词复数 )参考例句：Economic analysis of government interventions deserves detailed discussion. 政府对经济的干预应该给予充分的论述。 来自辞典例句The judges frequent interventions made a mockery of justice. 法官的屡屡干预是对正义的践踏。 来自互联网更多英语学习方法：企业英语培训