论文成果.doc
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1、 论文成果: PUBLICATIONS 1. Zhang, X-k., Huang, D.P., Chiu, D.K., and Chiu, J.F. The expression of oncogenes in human developing liver and hepatomas. Biochem. Biophys. Res. Comm. 142: 932-938. 1987. 2. Zhang, X-k., Wang, Z., Lee, A., Huang, D.P., and Chiu, J.F. Differential expression of cellular oncogen
2、es during rat liver development. Cancer Lett. 41: 147-155. 1988. 3. Li, P.M., Zhong, J.L., Chen, R.Q., Zhang, X-k., Ho, K.L., Chiu, J.F., and Huang, D.P. Zhi-mu saponin inhibits alpha-fetoprotein gene expression in developing rat liver. Int. J. Biochem. 21: 15-22. 1989. 4. Graupner, G., Wills, K.N.,
3、 Tzukerman, M., Zhang, X-k., and Pfahl, M. Dual regulatory role for thyroid-hormone receptors allows control of retinoic acid receptor activity. Nature (London) 340: 653-656. 1989. 5. Zhang, X-k., Huang, D.P., Qiu, D.K., and Chiu, J.F. The expression of c-myc and c-N-ras in human cirrhotic livers, h
4、epatocellular carcinomas and liver tissue surrounding the tumors. Oncogene 5: 909-914. 1990. 6. Hoffmann, B., Lehmann, J.M., Zhang, X-k., Hermann, T., Graupner, G., and Pfahl, M. A retinoic acid receptor-specific element controls the retinoic acid receptor- promoter. Mol. Endocrinol. 4: 1727-1736. 1
5、990. 7. Tzukerman, M., Zhang, X-k., Hermann, T., Wills, K.N., Graupner, G., and Pfahl, M. The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand. New Biol. 2: 613-620. 1990. 8. Pfahl, M., Tzukerman, M., Zhang, X-k., Lehmann, J.M., Hermann, T., Will
6、s, K.N., and Graupner, G. Nuclear retinoic acid receptors: cloning, analysis, and function. Methods Enzymol. 189: 256-270. 1990. 9. Zhang, X-k., Zucker, M.I., Huang, D.P., Lin, T-S., Prusoff, W.H., and Chiu, J.F. Alteration of cellular oncogene expression in L1210 cells by a nitrosoureaalalog of thy
7、midine. Cancer Comm. 3: 119-126. 1991. 10. Zhang, X-k., Dong, J.M., and Chiu, J.F. Regulation of -fetoprotein gene expression by antagonism between AP-1 and the glucocorticoid receptor at their overlapping binding site. J. Biol. Chem. 266: 8248-8254. 1991. 11. Graupner, G., Zhang, X-k., Tzukerman, M
8、., Wills, K.N., Hermann, T., and Pfahl, M. Thyroid hormone receptors repress estrogen receptor activation of a TRE. Mol. Endocrinol. 5: 365-372. 1991. 12. Hermann, T., Zhang, X-k., Tzukerman, M., Wills, K.N., Graupner, G., and Pfahl, M. Regulatory functions of a non-ligand-binding thyroid hormone re
9、ceptor isoform. Cell Regul. 2: 565-574. 1991. 13. Pfahl, M., Zhang, X-k., Lehmann, J.M., Husmann, M., Graupner, G., and Hoffmann, B. Molecular mechanisms of retinoic acid action. In G. Morriss-Kay (ed.), Retinoids in normal development and teratogenesis. Oxford University Press, Oxford. p. 51-64. 19
10、92. 14. Zhang, X-k., Wills, K.N., Graupner, G., Tzukerman, M., Hermann, T., and Pfahl, M. Ligand-binding domain of thyroid hormone receptors modulates DNA binding and determines their bifunctional roles. New Biol. 3: 169-181. 1991. 15. Wills, K.N., Zhang, X-k., and Pfahl, M. Coordinate expression of
11、 functionally distinct thyroid hormone receptor isoforms during neonatal brain development. Mol. Endocrinol. 5: 1109-1119. 1991. 16. Tzukerman, M., Zhang, X-k., and Pfahl, M. Inhibition of estrogen receptor activity by the tumor promoter 12-O-tetradeconylphorbol-13-acetate: a molecular analysis. Mol
12、. Endocrinol. 5: 1983-1992. 1991. 17. Yang-Yen, H-F*., Zhang, X-k.*, Graupner, G., Tzukerman, M., Sakamoto, B., Karin, M, and Pfahl, M. Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation. New. Biol. 3: 1206-1219. 1991. *Equal contribution. 18. Zhan
13、g, X-k., Tran, P.B., and Pfahl, M. DNA binding and dimerization determinants for thyroid hormone receptor and its interaction with a nuclear protein. Mol. Endocrinol. 5: 1909-1920. 1991. 19. Zhang, X-k., Wills, K.N., Husmann, M., Hermann, T., and Pfahl, M. Novel pathway for thyroid hormone receptor
14、action through interaction with junand fos oncogene activities. Mol. Cell. Biol. 11: 6016-6025. 1991. 20. Zhang, X-k., Hoffmann, B., Tran, P., Graupner, G., and Pfahl, M. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature (London) 355: 441-446. 1992.
15、21. Lehmann, J.M., Zhang, X-k., and Pfahl, M. RAR2 expression is regulated through a retinoic acid response element embedded in SP1 sites. Mol. Cell. Biol. 12: 2976-2985. 1992. 22. Hermann, T., Hoffmann, B., Zhang, X-k., Tran, P., and Pfahl, M. Heterodimeric receptor complexes determine 3,5,3-triiod
16、othyronine and retinoid signaling specificities. Mol. Endocrinol. 6: 1153-1162. 1992. 23. Zhang, X-k., Egan, J.O., Huang, D-p., Sun, Z.L., Chien, V.K., and Chiu, J.F. Hepatitis B virus DNA integration and expression of an erbB-like gene in human hepatocellular carcinoma. Biochem. Biophys. Res. Commu
17、n. 188: 344-351. 1992. 24. Tran, P., Zhang, X-k., Salbert, G., Hermann, T., Lehmann, J.M., and Pfahl, M. COUP orphan receptors are negative regulators of retinoic acid response pathways. Mol. Cell. Biol. 12: 4666-4676. 1992. 25. Zhang, X-k., Lehmann, J.M., Hoffmann, B., Dawson, M., Cameron, J., Grau
18、pner, G., Hermann, T., Tran, P., and Pfahl, M. Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid. Nature (London) 358: 587-591. 1992. 26. Hermann, T., Hoffmann, B., Piedrafita, F.J., Zhang, X-k., and Pfahl, M. V-erb A requires auxiliary proteins for dominant negative activity
19、. Oncogene. 8: 55-65. 1993. 27. Zhang, X-k. and Pfahl, M. Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors. Trends Endocrinol. Metab. 4: 156-162. 1993. 28. Lehmann, J.M., Zhang, X-k., Graupner, G., Lee, M.O., Hermann, T., Hoffmann, B., and Pfahl, M. F
20、ormation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching. Mol. Cell. Biol. 13: 7698-7707. 1993. 29. Zhang, X-k. and Pfahl, M. Hetero- and homodimeric receptors in thyroid hormone and vitamin A action. Receptor. 3: 183-191. 1993.
21、30. Zhang, X-k. and Pfahl, M. Molecular mechanisms of action for vitamin-A derived hormones in receptor-mediated biological processes. Implications for Evaluating Carcinogens. (ed. T.J. Slaga). Wiley-Liss Press. 1993. 31. Zhang, X-k., Salbert, G., Lee, M-O., and Pfahl, M. Mutations that alter ligand
22、-induced switches and dimerization activities in the retinoid X receptor. Mol. Cell. Biol. 14: 4311-4323. 1994. 32. Pfahl, M., Apfel, R., Bendik, I., Fanjul, A., Graupner, G., Lee, M-O., La-Vista, N., Lu, X-P, Piedrafita, J., Ortiz-Caseda, A., Salbert, G., and Zhang, X-k. Nuclear retinoid receptors
23、and their mechanism of action. Vitamins and hormones. (ed. Gerald Litwac). Vol. 49, pp. 327-382. 1994. 33. Lee, M-O., Hobbs, P.D., Zhang, X-k., Dawson, M.I., and Pfahl, M. A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter. Proc. Nat. Acad. Sci. 91: 5632-5636.
24、1994 34. Zhang, X-k., Liu, Y., Lee, M-O., and Pfahl, M. A specific defect in the retinoic acid response associated with human lung cancer cell lines. Cancer Res. 54: 5663-5669. 1994. 35. Zhang, X-k. Molecular mechanisms of action for vitamin A-derived hormones. Prog. Clin. Biol. Res. 387: 59-71. 199
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