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1、低分子肝素联合乙酰半胱氨酸治疗特发性间质性肺炎的疗效摘 要：目的 分析特l性间质性肺炎（idiopathic interstitial pneumonias，IIP）患者采取低分子肝素联合乙酰半胱氨酸的治疗效果。方法 回顾性选取2021年1月2021年1月枣庄市立医院新城院区呼吸内科收治的60例IIP患者作为研究对象，根据治疗方法不同分成研究组与常规组，每组30例。常规组患者采取常规治疗联合低分子肝素注射液，研究组患者在常规组治疗基础上联合应用乙酰半胱氨酸片。比较两组患者的治疗效果，治疗前后血清型胶原、高分辨率CT（HRCT）病变评分、6 min步行距离，动脉血二氧化碳分压（PaCO2）、动脉
2、血氧分压（PaO2）、用力肺活量（FVC）、第一秒用力呼气量（FEV1）以及一秒率（FEV1/FVC），不良反应发生情况。结果 研究组患者的总有效率明显高于常规组，差异有统计学意义（P 0.05）。治疗后，研究组与常规组患者的PaO2高于治疗前，PaCO2低于治疗前，差异有统计学意义（P 0.05）;且研究组患者PaO2高于常规组，PaCO2低于常规组，差异有统计学意义（P 0.05）。治疗后，两组患者HRCT病变评分与血清型胶原低于治疗前，6 min步行距离高于治疗前，差异有统计学意义（P 0.05）;且研究组患者HRCT病变评分与血清型胶原低于常规组，6 min步行距离高于常规组，差异有统
3、计学意义（P 0.05）。治疗后，两组患者FEV1、FVC及FEV1/FVC均高于治疗前，差异有统计学意义（P 0.05）;且研究组患者上述各指标高于常规组，差异有统计学意义（P 0.05）。两组患者不良反应发生率的差异无统计学意义（P 0.05）。结论 IIP患者采取低分子肝素注射液联合乙酰半胱氨酸片治疗，可提高治疗效果，对患者的肺功能、动脉血气指标改善较为明显，且安全性较好，值得应用。 关键词：醋酸泼尼松片;乙酰半胱氨酸;低分子肝素;特发性间质性肺炎;肺功能 中图分类号：R249 文献标识码：A 文章编号：1009-8011（2022）-6-000-04 The Therapeutic E
4、ffect of Low Molecular Weight Heparin Combined with Acetylcysteine in Patients with Idiopathic Interstitial Pneumonia HUA Ming-lei1 LIU Xiao-min1 XUE Jing2* （1.Respiratory department of Xincheng branch of Zaozhuang Municipal Hospital， Shandong Zaozhuang， 277300， China; 2.Department of Pharmacy， Medi
5、cal Supplies Center of PLA General Hospital， Beijing， 100039， China） Abstract： Objective To analyze the therapeutic effect of low molecular weight heparin combined with acetylcysteine in patients with idiopathic interstitial pneumonia. Methods Sixty patients with idiopathic interstitial pneumonia， w
6、ho were admitted to the Department of Respiratory Medicine， Xincheng District， Zaozhuang Municipal Hospital from January 2021 to January 2021， were retrospectively selected as the study subjects， and divided into the study group and the conventional group according to different treatment methods， wi
7、th 30 patients in each group. Patients in the conventional group received conventional treatment combined with low molecular weight heparin， and on the basis of the routine group， the treatment regimen of the research group was given low molecular weight heparin injection combined with acetylcystein
8、e tablets. The adverse study and therapeutic effects were compared between the study group and the conventional group. Serum collagen type ， HRCT lesion score， 6min walking distance， arterial partial pressure of carbon dioxide （PaCO2）， arterial partial pressure of oxygen （PaO2） forced vital capacity
9、 （FVC）， first second forced end-expiratory volume （FEV1）， and FEV1/FVC were compared before and after treatment between the study group and the conventional group. Results The total effective rate of the study group was 96.67%， higher than that of the conventional group 70.00% （P 0.05）. The PaO2 of
10、the study group was higher than that of the conventional group， while PaCO2 was lower than that of the conventional group （P 0.05）. After treatment， the HRCT lesion score and serum type collagen in the study group were lower than those in the conventional group， and the 6min walking distance was hig
11、her than that in the conventional group （P 0.05）. After treatment， patients in FEV、 FVC and FEV1/FVC group were higher than those in conventional group （P 0.05）. The incidence of adverse reactions was 3.33% in the study group and 6.67% in the conventional group （P 0.05）. Conclusion For patients with idiopathic interstitial pneumonia， low molecular weight heparin combined with acetylcysteine can effectively improve the therapeutic effect， lung function and arterial blood gas indicators of patients are significantly improved， which is worthy of wide application. 第 5 页 共 5 页