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1、Choose one which is the best answer in each question（40 1 point = 40 ）1. Immunological unresponsiveness to self antigens is called: ( A) ATolerance B Tolerogen CMemory DAcquired immunity 2. The signal transduction molecules associated with BCR are (B ) A. CD21 and CD81. B. Ignd Ig CD79a,b C. IgD and
2、 IgM. and ITIMs.3. T cells are MHC-restricted in their ability to respond to antigen because (D ) A. all antigen must be processed and presented to activate lymphocytes. B. during an infection, all cells in the body present antigen on MHC Class I. C. MHC binds antigen more specifically than TCR does
3、. D. TCR must recognize both antigen and MHC molecules. 4. An antibody Fab contains ( A B) A. complementarity determining regions. B. H and L chain variable regions. C. one antigen binding region. D. one H-L interchain disulfide bond. 5 Positive selection in the thymus is mediated by: ( A )A Thymic
4、epithelial cells. B Macrophages. CDendritic cells. DB-cells. 6. Type hypersentivity is often referred to as: ( B )A. Immediate hypersensitivity B. Delayed hypersensitivity C. Cytotoxic hypersensitivity D. Allergic hypersensitivity7. Type hypersentivity is often referred to as: ( C ) A. Immediate hyp
5、ersensitivity B. Delayed hypersensitivity C. Cytotoxic hypersensitivity D. Allergic hypersensitivity 精品资料 - - - 欢迎下载 - - - - - - - - - - - 欢迎下载 名师归纳 - - - - - - - - - -第 1 页，共 7 页 - - - - - - - - - - 8. Naive B cell expresses ( C ) A. IgA alone and IgG C IgM +IgD and Ig 9. T cell-derived cytokines (
6、 D ) A. are antigen-specific products of T cell activation B. are stored in the resting T cell and released on activation C. are MHC-restricted in their effects D. influence the class of antibodies produced by B cell10.Neutrophils are attracted to an infected area by ( C ) A. IgM B. C1 C. C5a D. C81
7、1.Complement lyses cells by ( C ) A. enzymatic digestion of the cell membrane B. activation of adenylate cyclase C. insertion of complement proteins into the cell membraneD. inhibition of elongation factor 2 12. CD8 is a marker of ( C)A. B cells B. Helper - T cells C. cytotoxic T cell D. M13. MHC cl
8、ass molecules are found on (B ) A. Virtually all cells in the body B. B cells, DC and M C. Virtually all nucleated cells in the body D. Only on virally-infected cells.14. All of following cytokines are secreted by Th2 cells except (B )A. IL-4 B. IFN- C. IL-5 D. IL-615. Which of the following is NOT
9、true of CD4+and CD8+cell markers? ( D ) A. These are both surface glycoproteins expressed on T-cells. B. These serve to distinguish different types of T-cells, ., helper, suppressor and cytotoxic, from each other. C. These are not found associated with immunoglobulins. 精品资料 - - - 欢迎下载 - - - - - - -
10、- - - - 欢迎下载 名师归纳 - - - - - - - - - -第 2 页，共 7 页 - - - - - - - - - - D. Both of the markers are present on ALL T-cells. 16. Cells bearing MHC class I plus peptide are targets for specific: ( B )A B-cells. B Cytotoxic T-cells. C Th1 cells. D Th2 cells. 17. Dendritic cells are characterized by: ( D )A
11、 the presence of major basic protein B expression of CD3 C expression of IgM molecules D their interface between the innate and adaptive immune system18. Which of the following uniquely distinguishes the T-cell receptor (TCR) from an antibody? ( A ) A. The TCR can bind an antigen fragment only in a
12、trimolecular complex with either the class I or class II surface proteins of the major histocompatibility complex B. The TCR can function as a cell surface antigen receptor C. The TCR is composed of two different types of polypeptide chains D. The TCR is capable of participating in a cytotoxic react
13、ion.19. A critical property of an antigen is ( A ) A. Its ability to stimulate an immune response B. a unique topological feature called an paratope C. not a unique topological feature called an antigenic determinant D. the size of which is relatively small of bacteria occurs through coating bacteri
14、a just with: ( A )A C3b B C8 C Membrane attack complex D IgM 21. The following is characteristic of B- but not T-cells: ( D )精品资料 - - - 欢迎下载 - - - - - - - - - - - 欢迎下载 名师归纳 - - - - - - - - - -第 3 页，共 7 页 - - - - - - - - - - A Class I MHC. B CD3. C HIV virus receptor. D Surface immunoglobulin.22Which
15、 of the following molecules is expressed on the surface of mature CD4+T cells? ( C )A. B cell receptor B. CD1d 23 The thymus is the site of initial differentiation for （ D ）A.B cells B. Erythrocytes C. Hematopietic stem cells D. T cells 24. The membrane attack complex consists of: ( C ) A OH B C3b3b
16、,Bb C C5b,6,7,8,9 D Properdin 25. Typ e hypersentivity is often referred to as: (A ) A. Immediate hypersensitivity B. Delayed hypersensitivity C. Cytotoxic hypersensitivity D. Immune complex hypersensitivity 26. Type hypersentivity is often referred to as: ( D) A. Immediate hypersensitivity B. Delay
17、ed hypersensitivity C. Cytotoxic hypersensitivity D. Immune complex hypersensitivity 27. The typehypersentivity is mediated by: ( D )A. IgA B. IgD C. IgG D. IgE 28. The cytokine which is most involved in the class switch to IgE production is: ( D ) beta 29. Which type hypersensitivity is related to
18、the mechanism of acute Arthus reaction: ( C )A. Type hypersentivity B. Type hypersentivity C. Type hypersentivity D. Type hypersentivity 精品资料 - - - 欢迎下载 - - - - - - - - - - - 欢迎下载 名师归纳 - - - - - - - - - -第 4 页，共 7 页 - - - - - - - - - - 30. T-cell CD40L provides a costimulatory signal to B-cells by l
19、igating: ( A )A CD40 B MHC class II C CD28 D CD19 31. Which immunoglobulin can be transported through the placenta? ( A )A. IgG B. IgM C. Secretory IgA D. IgE 32. Which immunoglobulin is the most one in the blood? ( A )A. IgG B. IgM C. Secretory IgA D. IgE 33. Which immunoglobulin can mediate the im
20、mediate hypersensitivity? ( D )A. IgG B. IgM C. Secretory IgA D. IgE 34. Molecules directly involved in NK cell mediated killing include: ( B )A nitric oxide B granzyme C complement D IFN- 35. Immune complexes consist of ( C ) A. antibody plus complement B. basophil plus complement C. antigen plus a
21、ntibody D. antigen plus complement36. The main costimulatory signal for activation of resting T-cells is provided by ligation of: ( A )A CD28 B Surface Ig C LFA-1 D VLA-4 37.The T-cell receptor antigen recognition signal is transduced by: ( E )A The TCR alpha chain. B The TCR beta chain. D CD2. E CD
22、3.38. The T-cell ligand binding B7 on a professional antigen-presenting cell is: AA CD28 B CD2 C LFA-1 D ICAM-1 39. Secondary antibody responses are better because: ( C) 精品资料 - - - 欢迎下载 - - - - - - - - - - - 欢迎下载 名师归纳 - - - - - - - - - -第 5 页，共 7 页 - - - - - - - - - - A They provide defense against
23、unrelated antigens B The antibody can be made by both T and B cells C They are stronger and faster D They do not require T-cell help 40. Which cell type produces antibodies?: ( D ) A Macrophages B T-lymphocytes C NK D Plasma cells II. Indicate whether each of the following statements is true or fals
24、e. （102 points =20 ）1. A hapten can stimulate antibody formation but cannot combine with antibody molecules. ( F)2. Booster shots are required because repeated exposure to an antigen builds a stronger immune response. ( T)3. The Ig/Ig heterodimer and CD3 serve analogous functions in the B-cell recep
25、tor and T-cell receptor, respectively. ( T )4. Antigen-presenting cells express both class I and class II MHC molecules on their membranes. ( T )5. Babies can acquire IgE-mediated allergies by passive transfer of maternal antibody. ( F )6. Both CTLs and NK cells release perforin after interacting wi
26、th target cells. ( T )7. Target cell lysis and destruction can be achieved by perforin released from antigen-specific cytotoxic T-cells ( T )8. The immune response is mediated via the humoral and/or cellular arms of the immune system ( T )9. Immediate type hypersensitivity is mediated by IgM. ( F )精
27、品资料 - - - 欢迎下载 - - - - - - - - - - - 欢迎下载 名师归纳 - - - - - - - - - -第 6 页，共 7 页 - - - - - - - - - - 10. All cytokine-binding receptors cintain two or three subunits. ( T ) Answer the following questions in brief （104points =40 ）1.Name the three types of professional APCs, and give one example of nonpr
28、ofessional APCs. B M DC endothelial cell2.Summarize the four major functions of complement system lysis of cells, bacteria and viruses opsonization to enhance phagocytosis clearance of immune complexes stimulation of inflammation3. List the classical Class I and Class II gene loci for humans 4. What
29、 dose MHC restriction mean?HLA-A,B,C HLA-DPDRDQ5. To activate T cells, two molecules must be recognized on the antigen-presenting cells, what are they? Peptide-MHC6. Compare the primary and secondary responses from the following points of view: (a) time for antibody to appear (b) quantity of antibod
30、y produced (c) class of antibody produced (d) duration of antibody production.7. Compare Class I and Class II MHC proteins from the following points of view: (a) types of cells on which they are located (b) role in antigen recognition by CD4+ and CD8+ T cells. 8. Helper T cells can be divided into t
31、wo subsets based on their lymphokine secretion profile. Explain. 9. What are the main functions of macrophages?10.Please draw a schematic diagram of a typical IgG molecule and label each part of the chains.精品资料 - - - 欢迎下载 - - - - - - - - - - - 欢迎下载 名师归纳 - - - - - - - - - -第 7 页，共 7 页 - - - - - - - - - -