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1、缺血性脑小血管病患者认知功能障碍与血清碱性磷酸酶的相关性【摘要】 目的：探缺血性脑小血管病（CSVD）患者认知功能障碍（CI）与血清碱性磷酸酶（ALP）的相关性。方法：选择2021年1月-2021年7月就诊于九江市第一人民医院的84例CSVD患者，按照其是否存在CI分为两组，将存在CI的43例患者设为研究组，将41例无CI患者设为认知正常组，同期另选择40例健康体检者为对照组。测定三组受检者血清ALP水平，比较三组血清ALP水平、蒙特利尔认知评估量表（MoCA）评分，分析CSVD患者CI与血清ALP的相关性。结果：研究组血清ALP水平高于认知正常组、对照组，MoCA评分低于认知正常组、对照组，
2、差异均有统计学意义（P 0.05）;认知正常组血清ALP水平高于对照组，差异有统计学意义（P 0.05）;认知正常组与对照组MoCA评分比较，差异无统计学意义（P 0.05）。Pearson相关性分析显示：CSVD患者MoCA评分与血清ALP水平呈负相关（r=-0.942，P 0.05）。结论：CSVD患者体内ALP水平升高，其水平与CI密切相关。 【关键词】 缺血性脑小血管病 碱性磷酸酶 认知功能障碍 相关性 Correlation between Cognition Impairment and Serum Alkaline Phosphatase in Patients with Isc
3、hemic Cerebral Small Vascular Disease/XIAO Ting， PAN Zhibin. /Medical Innovation of China， 2021， 18（36）： 0-063 Abstract Objective： To investigate the correlation between cognition impairment （CI） and serum alkaline phosphatase （ALP） in patients with ischemic cerebral small vascular disease （CSVD）. M
4、ethod： A total of 84 CSVD patients who were treated in the Jiujiang First Peoples Hospital from January 2021 to July 2021 were selected and divided into two groups according to the presence or absence of CI， 43 patients with CI were selected as the study group， 41 patients without CI were selected a
5、s the cognitive normal group， and 40 healthy physical examiners were selected as the control group in the same period. The serum ALP levels of the three groups were measured， the serum ALP levels of the three groups and the score of Montreal cognitive assessment scale （MoCA） were compared， and the c
6、orrelation between CI and serum ALP in CSVD patients was analyzed. Result： The serum ALP level of the study group was higher than that of the cognitive normal group and the control group， and the MoCA score was lower than that of the cognitive normal group and the control group， the differences were
7、 statistically significant （P 0.05）; the level of serum ALP in the cognitive normal group was significantly higher than that in the control group， the differenence was statistically significant （P 0.05）; there was no significant difference in MoCA score between cognitive normal group and control gro
8、up （P 0.05）. Pearson correlation analysis showed that there was a negative correlation between MoCA score and serum ALP level in CSVD patients （r=-0.942， P 0.05）. Conclusion： The level of ALP in patients with CSVD increased， which is closely correlated with CI. Key words Ischemic cerebral small vascular disease Alkaline phosphatase Cognition impairment Correlation 第 3 页 共 3 页